Royal Papworth Hospital is the only centre in the UK offering the pulmonary endarterectomy (PEA, also known as PTE) procedure and has performed more than 1,900 operations since 1996. We are one of the most active centres in the world, carrying out up to 200 PEA operations per year, with some of the best long-term outcomes internationally.

Pulmonary endarterectomy is a surgical operation in which the blood vessels of the lungs are cleared of clot and scar material. In a large proportion of patients who undergo this operation, their level of activity, quality of life and life expectancy are significantly improved and pulmonary endarterectomy surgery can be thought of as a cure for most patients.


What is Chronic Thromboembolic Pulmonary Hypertension (CTEPH)?

CTEPH is a form of pulmonary hypertension that occurs as the result of blood clots blocking off the arteries of the lungs. While most of these blood clots originate in the veins, many people with this condition may be unaware that these clots are forming. Over time, the blood clots build up in the blood vessels of the lungs which become permanently scarred with narrowing and decreased blood flow. This results over time in increased pressure and resistance to blood flow in the lungs leading to pulmonary hypertension and right heart failure. When severe, this situation leads to increasing breathlessness, exercise limitation and reduced life expectancy.

 

What is the pulmonary endarterectomy procedure?

PEA is a surgical operation in which the blood vessels of the lungs are cleared of clot and scar material and usually takes 8-10 hours. The patient is attached to a heart-lung bypass machine prior to their body temperature being cooled to 20°C which reduces the body’s oxygen requirement and provides protection to organs of the body during the surgery. During the critical part of the surgery where the clots and scarring are removed the heart-lung bypass machine is turned off for up to 20 minutes to create a bloodless field. The bypass machine is then turned back on to re-perfuse the body’s organs again before it is turned off to remove the clots and scarring from the other lung. Research led by the Royal Papworth PEA team has shown that this is safest way to perform this operation.

Although the operation sounds simple, it is actually technically very difficult to get access to the arteries of the lungs, and the procedure itself is a major undertaking. For this reason it is necessary to ensure that patients who might potentially benefit from this operation are thoroughly evaluated. Not everyone with CTEPH will be suitable for this operation, and a number of additional investigations must be performed in order to assess the appropriateness of surgery and the level of risk involved. However in a large proportion of patients who undergo this operation, their level of activity, quality of life and life expectancy are significantly improved and pulmonary endarterectomy surgery can be thought of as a cure for most patients.

Prior to being accepted for surgery, you will have the opportunity to discuss the operation in detail with the surgeon and other members of the team at Royal Papworth Hospital. Should you or your family have any questions or concerns they will be happy to address them prior to any decisions being made. You can download a copy of the patient’s guide and agreement to consent information booklet and the pulmonary endarterectomy guide.

 

What if I am not suitable for surgery?

The majority of patients (70-80%) referred to our service will benefit from surgery. Occasionally the type of disease may not be appropriate for surgery, or the patient may be too well or unwell to undergo the operation. In this circumstance you will be followed carefully and there may be some medical treatments available that can help improve the severity of pulmonary hypertension. At present, Royal Papworth Hospital is working closely with other centres around the world to develop more effective treatments for this condition.

 

Royal Papworth Hospital's pulmonary endarterectomy surgeons:

Clinical Director of Surgery and Transplantation
Mr David Jenkins

Mr Steven Tsui
Mr Choo Yen Ng
Mr John Taghavi

 

Further information

If you would like further information regarding CTEPH or pulmonary endarterectomy (PEA) please email our PEA Specialist Nurses at phn-tr.PTENurses@nhs.net.


 

Patient guides

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Pulmonary Endarterectomy - a patient guide and agreement to consent form
Pulmonary Endarterectomy (PEA) - a patient's guide
Pulmonary Endarterectomy discharge information (PEA)

 

Video Guide: Preparing for Pulmonary Endarterectomy surgery

This film has been produced to help patients and their families prepare for undergoing pulmonary endarterectomy surgery at Papworth; it outlines practical ways of helping to prepare for going home after surgery. (Runtime 29.34)


 

Where are we based?

Royal Papworth Hospital NHS Foundation Trust
Papworth Everard
Cambridge
Cambridgeshire
CB23 3RE

Telephone:  01480 830541

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