Research projects

• QUACS: Quality of life After Cardiac Surgery: a national multicentre observational study.  Click here to read the protocol.  CI Mr S. Nashef Sponsor: Papworth Hospital NHS Foundation Trust

• NOTACS: Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: a multicentre randomised controlled trial with participating sites in the UK, Australia and New Zealand.  CI Dr A Klein .  Sponsor: Papworth Hospital NHS Foundation Trust. NOTACS is registered on ClinicalTrials.gov.  Below are links to two articles with further information about NOTACS:

         A patient's experience of taking part in NOTACS

         NOTACS article on Royal Papworth Website

• AMAZE: A randomized controlled trial to investigate the clinical and cost-effectiveness of adding an ablation device-based maze procedure as a routine adjunct to elective cardiac surgery for patients with pre-existing atrial fibrillation (AF). ISRCTN82731440 UKCRN ID 5245. Click here for further details. CI Mr S. Nashef Sponsor: Royal Papworth Hospital NHS Foundation Trust
• ETTAA: Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A prospective cohort study. ISRCTN 04044627 UKCRN ID 15992. Website: http://ettaastudy.com/; CI Mr S Large Sponsor: Papworth Hospital NHS Foundation Trust   ETTAA Systematic Review Paper was published in March 2021 in BMJ Open.  Click here to read the article.  The first ETTAA results paper has been published in the European Heart Journal.  Click here to read the paper.

• BIOPATTERN: Site of disease BIOmolecule capture and analysis in PATienTs with established coronary disease undERgoing iNtracoronary assessment.  CI: Dr Stephen Hoole.  Sponsor: Papworth Hospital NHS Foundation Trust.  Click here for an article about the study.
• CAIS: Cardiovascular Acoustics and an Intelligent Stethoscope.  An observational study to collect heart sound recordings from patients to understand the acoustic characteristics of murmurs and develop an artificially intelligent stethoscope.  Find out more about the study.  CI Dr B Rana. Sponsor: Papworth Hospital NHS Foundation Trust and Cambridge University.
• EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary here;CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
• DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
• RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. For further information click here.  CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
• TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information HERE; CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
• The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar; Sponsor: Papworth Hospital NHS Foundation Trust                                                           

• SINTAVA: Ablation targets for ventricular tachycardia. CI Dr C Martin. Sponsor: Royal Papworth Hospital NHS Foundation Trust https: //www.clairemartincardiologist.com/research

• CRAFT: Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter. PI Dr C Martin. Sponsor: Liverpool Heart and Chest Hospital https://clinicaltrials.gov/ct2/show/NCT03401099

• COHORT substudy: Minimally-invasive phenotyping of arrhythmias in idiopathic pulmonary arterial hypertension. A sub-study of the National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension. PI Dr C Martin and Dr M Toshner. Sponsor: Royal Papworth Hospital NHS Foundation Trust http://www.ipahcohort.com/

• PRAETORIAN-DFT: A Prospective Randomised Comparative trial of Subcutaneous Implantable Cardioverter-Defibrillator Implantation with and without Defibrillation Testing. CI Dr C Martin. Sponsor: Academic Medical Center, Amsterdam, the Netherlands https://clinicaltrials.gov/ct2/show/NCT03495297

• INTERRUPT-AF: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation. CI Dr C Martin. Sponsor: Boston Scientific https://clinicaltrials.gov/ct2/show/NCT03729830

• PSOT: All Inclusive KODEX - EPD™ Patient Specific Optimized Therapy Study. CI Dr C Martin. Sponsor: EPD Research Ltd https://clinicaltrials.gov/ct2/show/NCT03619018

• SPORT: Second Primary lung cancer cohORT study.  CI: Dr R. Rintoul, Sponsor: Royal Papworth Hospital NHS Foundation Trust.  Click here for further information​​​​​​.

• TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), Sponsor: Papworth Hospital NHS Foundation Trust

CI Prof T Eisen Click here for further information and Here

• Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157

• MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial.  Visit the clinical trials.gov website for further information for further information. CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust

• Multiparametric MRI to assess treatment response in mesothelioma Click here for further information CI Dr Nagmi Qureshi; Sponsor: Papworth Hospital NHS Foundation Trust

• PAPLAND: Routine cardiac screening in sarcoidosis patients. UK CI: Dr M Thillai, UK Sponsor: Royal Papworth Hospital NHS Foundation Trust.  The study is funded and led by The Foundation for Sarcoidosis Research based in the USA.  Click here for further information about the study.

   

• CASPA (CArdiac Sarcoidosis in PApworth): Improving the diagnosis of cardiac disease in patients with pulmonary sarcoidosis. Click HERE for further information CI Dr Muhunthan Thillai Sponsor: Royal Papworth Hospital NHS Foundation Trust

• SAFESCAN: Developing a non-contact sleep apnoea detector, suitable for home studies.  CI Dr I Smith, Sponsor: Royal Papworth Hospital NHS Foundation Trust.  Please click here for further information.
• MATHS (Mathematically Arterialised Testing of Hypercapnic Subjects).  Role of mathematically arterialised venous blood sampling in the assessment and management of adult subjects with respiratory failure; a prospective observational cohort study to investigate the physiological agreement between arterial sampling (the reference method) and mathematically arterialised venous blood.  CI Dr M Davies, Sponsor: Royal Papworth Hospital NHS Foundation Trust.  Click here for further information.  

• StratosPHere: Optimal biomarkers to ascertain target engagement in therapies targeting the BMPR2 pathway in Pulmonary Arterial Hypertension (PAH). Sponsor: University of Cambridge & Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
• StratosPHere 2: Stratified adaptive therapeutic studies in pulmonary arterial hypertension caused by mutations in BMPR2. Sponsor: Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
• TRANSFORM: TRANSFORM-PAH: TheRApeutic opeN label Study of tocilizumab FOR the Management of PAH Sponsor: Papworth Hospital NHS Foundation Trust CI Dr Mark Toshner www.transform-uk.com 

• NOMAB: Phase II Study of a Nebulised Nitric Oxide Generating Solution in Patients With Cystic Fibrosis. Sponsor: Papworth Hospital Foundation Trust. CI's: Dr Charles Haworth & Professor R. Andres Floto.  Further information can be found at clinicaltrials.gov.

• HICC: Humoral Immune Correlates of COVID-19. CI Dr Helen Baxendale. Sponsor: Royal Papworth Hospital NHS Foundation Trust