• AMAZE: A randomized controlled trial to investigate the clinical and cost-effectiveness of adding an ablation device-based maze procedure as a routine adjunct to elective cardiac surgery for patients with pre-existing atrial fibrillation (AF). ISRCTN82731440 UKCRN ID 5245. Click here for further detail. CI Mr S. Nashef Sponsor: Royal Papworth Hospital NHS Foundation Trust
• MINISTERN: A pragmatic, prospective, randomised controlled trial comparing upper ministernotomy to full median sternotomy as a surgical approach for aortic valve replacement. UKCRN ID 7766. Click here for the protocol. CI Mr S Nair Sponsor: Papworth Hospital NHS Foundation Trust
• Emphasis: Hemodynamic performance of the Carpentier-Edwards PERIMOUNT Magna Ease aortic bioprosthesis. Click Here for further information; CI Mr J Dunning Sponsor: Papworth Hospital NHS Foundation Trust
• ETTAA: Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A prospective cohort study. ISRCTN 04044627 UKCRN ID 15992. Website: http://ettaastudy.com/; CI Mr S Large Sponsor: Papworth Hospital NHS Foundation Trust

• EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary here;CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
• DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
• HESTER: Has Electrical Sinus Translated into Effective Remodelling. UKCRN ID 15261. Click here for further information. CI Mr S. Nashef Sponsor: Papworth Hospital NHS Foundation Trust
• RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. For further information click here.  CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
• TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information HERE; CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
• The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar; Sponsor: Papworth Hospital NHS Foundation Trust                                                           

• SINTAVA: Ablation targets for ventricular tachycardia. CI Dr C Martin. Sponsor: Royal Papworth Hospital NHS Foundation Trust https: //www.clairemartincardiologist.com/research

• CRAFT: Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter. PI Dr C Martin. Sponsor: Liverpool Heart and Chest Hospital https://clinicaltrials.gov/ct2/show/NCT03401099

• COHORT substudy: Minimally-invasive phenotyping of arrhythmias in idiopathic pulmonary arterial hypertension. A sub-study of the National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension. PI Dr C Martin and Dr M Toshner. Sponsor: Royal Papworth Hospital NHS Foundation Trust http://www.ipahcohort.com/

• PRAETORIAN-DFT: A Prospective Randomised Comparative trial of Subcutaneous Implantable Cardioverter-Defibrillator Implantation with and without Defibrillation Testing. CI Dr C Martin. Sponsor: Academic Medical Center, Amsterdam, the Netherlands https://clinicaltrials.gov/ct2/show/NCT03495297

• INTERRUPT-AF: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation. CI Dr C Martin. Sponsor: Boston Scientific https://clinicaltrials.gov/ct2/show/NCT03729830

• PSOT: All Inclusive KODEX - EPD™ Patient Specific Optimized Therapy Study. CI Dr C Martin. Sponsor: EPD Research Ltd https://clinicaltrials.gov/ct2/show/NCT03619018

• TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), Sponsor: Papworth Hospital NHS Foundation Trust

CI Prof T Eisen Click here for further information and Here

• Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157

• MARS2: A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma. UKCRN ID 15909. Click here for Further Information;CI Mr E Lim, Sponsor: Royal Brompton & Harefield NHS Trust

• MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. Click here for further information. CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust

• Multiparametric MRI to assess treatment response in mesothelioma Click here for further information CI Dr Nagmi Qureshi; Sponsor: Papworth Hospital NHS Foundation Trust

• CASPA (CArdiac Sarcoidosis in PApworth): Improving the diagnosis of cardiac disease in patients with pulmonary sarcoidosis. Click HERE for further information CI Dr Muhunthan Thillai Sponsor: Papworth Hospital NHS Foundation Trust

• MIMOSA Study: Effect of acute intravenous morphine administration on Sleep Disordered Breathing (SDB) and sleep architecture in patients with moderate Obstructive Sleep Apnoea (OSA): A randomised controlled trial. CI Dr Ian Smith, Sponsor: Papworth Hospital NHS Foundation Trust. Further information                                                                                                                                                           
• POSAG Trial: Prevalence of Obstructive Sleep Apnoea in Glaucoma    Prospective observational controlled trial of the prevalence of obstructive sleep apnoea in patients with open­ angle glaucoma. Sponsor: Papworth Hospital NHS Foundation Trust, CI Dr Ian Smith, PI Dr Dariusz Wozniak, Contact for further information

• PAIR Study Intraocular pressure changes in response to continuous positive airway pressure during diurnal trial in people with treated primary open-angle glaucoma, treatment naïve primary open-angle glaucoma patients and control subjects. Sponsor: Papworth Hospital NHS Foundation Trust. CI Dr Ian Smith.  Further information

• PCOSA-1: PFO closure for obstructive sleep apnoea. Please click here for further information

• TRANSFORM: TRANSFORM-PAH: TheRApeutic opeN label Study of tocilizumab FOR the Management of PAH Sponsor: Papworth Hospital NHS Foundation Trust CI Dr Mark Toshner www.transform-uk.com 

• SmartCare: A multi-centre feasibility study of remote monitoring in adult CF patients. UKCRN ID. Click here for further detail CI Prof A Floto Sponsor: Papworth Hospital NHS Foundation Trust