Lay summaries for current and completed projects can be found in the PPI section

Heart research

  • NOTACS: Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: a multicentre randomised controlled trial with participating sites in the UK, Australia and New Zealand.  CI Dr A Klein .  Sponsor: Papworth Hospital NHS Foundation Trust. NOTACS is registered on  Below are links to two articles with further information about NOTACS:

         A patient's experience of taking part in NOTACS

         NOTACS article on Royal Papworth Website

Cardiology: Interventional, Medicinal, Observational
  • CRAFT: Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter. PI Dr C Martin. Sponsor: Liverpool Heart and Chest Hospital
  • COHORT substudy: Minimally-invasive phenotyping of arrhythmias in idiopathic pulmonary arterial hypertension. A sub-study of the National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension. PI Dr C Martin and Dr M Toshner. Sponsor: Royal Papworth Hospital NHS Foundation Trust
  • PRAETORIAN-DFT: A Prospective Randomised Comparative trial of Subcutaneous Implantable Cardioverter-Defibrillator Implantation with and without Defibrillation Testing. CI Dr C Martin. Sponsor: Academic Medical Center, Amsterdam, the Netherlands
  • INTERRUPT-AF: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation. CI Dr C Martin. Sponsor: Boston Scientific

Lung research

Surgery / Transplant
Lung Cancers
  • TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), Sponsor: Papworth Hospital NHS Foundation Trust

CI Prof T Eisen Click here for further information and Here

  • Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157
  • MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial.  Visit the clinical website for further information for further information. CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust
Sleep Disorders
Pulmonary Hypertension
  • StratosPHere: Optimal biomarkers to ascertain target engagement in therapies targeting the BMPR2 pathway in Pulmonary Arterial Hypertension (PAH). Sponsor: University of Cambridge & Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
  • StratosPHere 2: Stratified adaptive therapeutic studies in pulmonary arterial hypertension caused by mutations in BMPR2. Sponsor: Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
  • TRANSFORM: TRANSFORM-PAH: TheRApeutic opeN label Study of tocilizumab FOR the Management of PAH Sponsor: Papworth Hospital NHS Foundation Trust CI Dr Mark Toshner 
Cystic Fibrosis


  • HICC: Humoral Immune Correlates of COVID-19. CI Dr Helen Baxendale. Sponsor: Royal Papworth Hospital NHS Foundation Trust