Lay summaries for current and completed projects can be found in the PPI section

Heart research

Surgery

         A patient's experience of taking part in NOTACS

         NOTACS article on Royal Papworth Website

  • AMAZE: A randomized controlled trial to investigate the clinical and cost-effectiveness of adding an ablation device-based maze procedure as a routine adjunct to elective cardiac surgery for patients with pre-existing atrial fibrillation (AF). ISRCTN82731440 UKCRN ID 5245. Click here for further details. CI Mr S. Nashef. Sponsor: Royal Papworth Hospital NHS Foundation Trust
  • ETTAA: Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A prospective cohort study. ISRCTN 04044627 UKCRN ID 15992. Website: http://ettaastudy.com/; CI Mr S Large.  Sponsor: Royal Papworth Hospital NHS Foundation Trust   
    ETTAA Systematic Review Paper was published in March 2021 in BMJ Open.  Click here to read the article. 
    The first ETTAA results paper has been published in the European Heart Journal.  Click here to read the paper.
Cardiology: Interventional, Medicinal, Observational
  • BIOPATTERN: Site of disease BIOmolecule capture and analysis in PATienTs with established coronary disease undERgoing iNtracoronary assessment.  CI: Dr Stephen Hoole.  Sponsor: Royal Papworth Hospital NHS Foundation Trust.  Click here for an article about the study.
  • CAIS: Cardiovascular Acoustics and an Intelligent Stethoscope.  An observational study to collect heart sound recordings from patients to understand the acoustic characteristics of murmurs and develop an artificially intelligent stethoscope.  Find out more about the study.  CI Dr B Rana. Sponsor: Royal Papworth Hospital NHS Foundation Trust and Cambridge University.
  • EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary here.  CI Dr S Hoole.  Sponsor: Royal Papworth Hospital NHS Foundation Trust 
  • DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole.  Sponsor: Royal Papworth Hospital NHS Foundation Trust
  • RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. For further information click here.  CI Dr S Hoole.  Sponsor: Royal Papworth Hospital NHS Foundation Trust.
    View the RITA-MI lay summary.
  • TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information hereCI Dr S Hoole.  Sponsor: Royal Papworth Hospital NHS Foundation Trust.
    View the TIMES lay summary.
  • The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar.   Sponsor: Papworth Hospital NHS Foundation Trust.                                                    
Electrophysiology
  • CRAFT: Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter. PI Dr C Martin. Sponsor: Liverpool Heart and Chest Hospital https://clinicaltrials.gov/ct2/show/NCT03401099
  • COHORT substudy: Minimally-invasive phenotyping of arrhythmias in idiopathic pulmonary arterial hypertension. A sub-study of the National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension. PI Dr C Martin and Dr M Toshner. Sponsor: Royal Papworth Hospital NHS Foundation Trust http://www.ipahcohort.com/
  • PRAETORIAN-DFT: A Prospective Randomised Comparative trial of Subcutaneous Implantable Cardioverter-Defibrillator Implantation with and without Defibrillation Testing. CI Dr C Martin. Sponsor: Academic Medical Center, Amsterdam, the Netherlands https://clinicaltrials.gov/ct2/show/NCT03495297
  • INTERRUPT-AF: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation. CI Dr C Martin. Sponsor: Boston Scientific https://clinicaltrials.gov/ct2/show/NCT03729830

Lung research

Surgery / Transplant
Lung Cancers
  • SPORT: Second Primary lung cancer cohORT study.  CI: Dr R. Rintoul. Sponsor: Royal Papworth Hospital NHS Foundation Trust  Click here for further information.
    View the SPORT lay summary.​​​​​​
  • TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), Sponsor: Royal Papworth Hospital NHS Foundation Trust

CI: Prof T Eisen. Click here for further information and here.

  • Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157
Mesothelioma
  • MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial.  Visit the clinical trials.gov website for further information for further information. CI Dr R Rintoul. Sponsor: Royal Papworth Hospital NHS Foundation Trust
Sarcoidosis
Sleep Disorders
  • PAPMAT: Continuous Positive Airway Pressure plus Mandibular Advancement Therapy: does combining two effective treatments improve outcomes in Obstructive Sleep Apnoea?  Does combining MAD with CPAP therapy make it easier for patients to tolerate CPAP, thereby increasing adherence to treatment and improving patient reported outcome measures (PROMs) ?  CI: Dr T Quinnell.  Sponsor: Royal Papworth Hospital NHS Foundation Trust. View the ISRCTN registry here .
  • MATHS (MathematicallMATHS (Mathematically Arterialised Testing of Hypercapnic Subjects).  Role of mathematically arterialised venous blood sampling in the assessment and management of adult subjects with respiratory failure; a prospective observational cohort study to investigate the physiological agreement between arterial sampling (the reference method) and mathematically arterialised venous blood. CI Dr M Davies. Sponsor: Royal Papworth Hospital NHS Foundation Trust.  Click here for further information.  
Pulmonary Hypertension
  • StratosPHere: Optimal biomarkers to ascertain target engagement in therapies targeting the BMPR2 pathway in Pulmonary Arterial Hypertension (PAH). Sponsor: University of Cambridge & Royal Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
  • StratosPHere 2: Stratified adaptive therapeutic studies in pulmonary arterial hypertension caused by mutations in BMPR2. Sponsor: Royal Papworth Hospital Foundation Trust. CI: Dr Mark Toshner
  • TRANSFORM: TRANSFORM-PAH: TheRApeutic opeN label Study of tocilizumab FOR the Management of PAH Sponsor: Royal Papworth Hospital NHS Foundation Trust. CI: Dr Mark Toshner www.transform-uk.com 
Cystic Fibrosis
  • Project Breathe.  Analysis of remote monitoring/virtual clinic data in adult patients with Cystic Fibrosis (CF).​​​​Sponsor: Royal Papworth Hospital Foundation Trust.  CI: Professor R. Andres Floto.
  • ACE-CF.  Artificial intelligence to Control acute pulmonary Exacerbations in Cystic Fibrosis.  Sponsor: Royal Papworth Hospital Foundation Trust.  CI: Professor R. Andres Floto.

Other

COVID
  • HICC: Humoral Immune Correlates of COVID-19. CI Dr Helen Baxendale. Sponsor: Royal Papworth Hospital NHS Foundation Trust