Cardiac Surgery
MINISTERN: A pragmatic, prospective, randomised controlled trial comparing upper ministernotomy to full median sternotomy as a surgical approach for aortic valve replacement. UKCRN ID 7766. Click here for the protocol. CI Mr S Nair Sponsor: Papworth Hospital NHS Foundation Trust
Emphasis: Hemodynamic performance of the Carpentier-Edwards PERIMOUNT Magna Ease aortic bioprosthesis. Click Here for further information; CI Mr J Dunning Sponsor: Papworth Hospital NHS Foundation Trust
ETTAA: Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A prospective cohort study. ISRCTN 04044627 UKCRN ID 15992. Website: http://ettaastudy.com/; CI Mr S Large Sponsor: Papworth Hospital NHS Foundation Trust
CARDIOLOGY: Interventional, Medicinal, Observational
EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary HERE; CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole Sposnor: Papworth Hospital NHS Foundation Trust
Gold PCI: A study to investigate the protective effects of Glucagon-like Peptide-1 (GLP-1) in patients undergoing elective angioplasty and stenting. CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
HESTER: Has Electrical Sinus Translated into Effective Remodelling. UKCRN ID 15261. Click here for further information. CI Mr S. Nashef Sponsor: Papworth Hospital NHS Foundation Trust
RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. Further information HERE CI Dr S Hoole, Sponsor: Papworth Hospital NHS Foundation Trust
TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information HERE; CI: Dr S Hoole, Sponsor: Papworth Hospital NHS Foundation Trust
The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar; Sponsor: Papworth Hospital NHS Foundation Trust
Lung Cancers
TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), CI: Sponsor: Papworth Hospital NHS Foundation Trust
CI Prof T Eisen Click here for further information and Here
Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157
Mesothelioma
MARS2: A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma. UKCRN ID 15909. Click here for Further Information;CI Mr E Lim, Sponsor: Royal Brompton & Harefield NHS Trust
MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. Click HERE for further information; CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust
Multiparametric MRI to assess treatment response in mesothelioma Click here for further information CI Dr Nagmi Qureshi; Sponsor: Papworth Hospital NHS Foundation Trust
Sarcoidosis
CASPA (CArdiac Sarcoidosis in PApworth): Improving the diagnosis of cardiac disease in patients with pulmonary sarcoidosis. Click HERE for further information CI Dr Muhunthan Thillai Sponsor: Papworth Hospital NHS Foundation Trust
Sleep Disorders
MIMOSA Study: Effect of acute intravenous morphine administration on Sleep Disordered Breathing (SDB) and sleep architecture in patients with moderate Obstructive Sleep Apnoea (OSA): A randomised controlled trial. CI Dr Ian Smith, Sponsor: Papworth Hospital NHS Foundation Trust. Further information
POSAG Trial: Prevalence of Obstructive Sleep Apnoea in Glaucoma Prospective observational controlled trial of the prevalence of obstructive sleep apnoea in patients with open angle glaucoma. Sponsor: Papworth Hospital NHS Foundation Trust, CI Dr Ian Smith, PI Dr Dariusz Wozniak, Contact for further information
PAIR Study Intraocular pressure changes in response to continuous positive airway pressure during diurnal trial in people with treated primary open-angle glaucoma, treatment naïve primary open-angle glaucoma patients and control subjects. Sponsor: Papworth Hospital NHS Foundation Trust. CI Dr Ian Smith. Further information
PCOSA-1: PFO closure for obstructive sleep apnoea. Please click here for further information
Pulmonary Hypertension
TRANSFORM: TRANSFORM-PAH: TheRApeutic opeN label Study of tocilizumab FOR the Management of PAH Sponsor: Papworth Hospital NHS Foundation Trust CI Dr Mark Toshner www.transform-uk.com
Cystic Fibrosis
SmartCare: A multi-centre feasibility study of remote monitoring in adult CF patients. UKCRN ID. Click here for further detail CI Prof A Floto Sponsor: Papworth Hospital NHS Foundation Trust
ReCliC: The Repurposing of Clinical Data for Quality Improvement in Critical Care. Click HERE for further information. CI: Dr M Jones, Sponsors: Papworth NHS Hospital Foundation Trust and the University of Cambridge
