Papworth Trials Unit Collaboration publications

Details of PTUC publications are provided below;

• The potential of breath analysis to improve outcome for patients with lung cancer.  Antoniou SX, Gaude E, Ruparel M, van der Schee MP, Janes SM, Rintoul RC & The LuCID Group.  Journal of Breath Research Volume 13, Issue 13: 24 April 2019.  View here

• The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial. Giblett JP, Clarke S, Zhao T, McCormick LM, Braganza DM, Denem CG, O'Sullivan M, Adlam D, Clarke SC, Steele J, Fielding S, West NEJ, Villar SS & Hoole SP.  American Heart Journal Volume: 215, 9 June 2019.  View here   

• Mini-Stern Trial: A randomized trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement.  Nair SK, Sudarshan CD, Thorpe BS, Singh J, Pillay T, Catarino P, Valchanov K, Codispoti M, Dunning J, Abu-Omar Y, Moorjani N, Matthews C, Freeman CJ, Fox-Rushby JA & Sharples LD.  The Journal of Thoracic and Cardiovascular Surgery Volume 156, Issue 6: December 2018    View here

• Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation. Sharples L, Everett C, Singh J, Mills C, Spyt T, Abu-Omar Y, Fynn S, Thorpe B, Stoneman V, Goddard H, Fox-Rushby J & Nashef S. Health Technology Assessment Volume: 22, Issue: 19, April 2018 View here
• Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study.  Hoole S P, Hernández-Sánchez J, Davies W R, McNab D C, Calvert P A, Rana B S, Shapiro L M & Davies M G.  Canadian Journal of Cardiology, December 2017, 33,12 (1708-1715).  View here
• ​Recovery of Left Atrial Contractile Function After Maze Surgery in Persistent Longstanding Atrial Fibrillation. Yasir Abu-Omar, Samar Nashef et al. JACC 7, 16, Oct.2017. View here
• Clinical trial protocol for TRANSFORM-UK: A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertension. Jules Hernandez-Sanchez, Louise Harlow, Mark Toshner et al. Pulmonary Circulation,  28 Sep 2017. View here
• The ETTAA study protocol: a UK-wide observational study of 'Effective Treatments for Thoracic Aortic Aneurysm'. Sastry, P., Hughes, V., Hayes, P., Vallabhaneni, S., Sharples, L., Thompson, M., Catarino, P., Moorjani, N., Vale, L., Gray, J., Cook, A., Elefteriades, J. A. & Large, S. R. 2015BMJ Open, 5, e008147.. BMJ Open. 2015 Jun 2;5(6) View here
• Cost-effectiveness of initial stress cardiovascular MR, stress SPECT or stress echocardiography as a gate-keeper test, compared with upfront invasive coronary angiography in the investigation and management of patients with stable chest pain: mid-term outcomes from the CECaT randomised controlled trial. Crean A et al. BMJ Open. 2014 Feb 7;4(2) View here
• Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer: results from the ASTER randomised controlled trial. Sharples, L., Jackson, C., Wheaton, E., Griffith, G., Annema, J., Dooms, C., Tourney, K., Deschepper, E., Hughes, V., Magee, L., Buxton, M. & Rintoul, R. Health Technology Assessment, 16, 1-83. 2012; 16 (18):1-83)  View here
• Multicentre trial of weekly risedronate on bone density in adults with cystic fibrosis. Haworth C, Sharples L, Hughes V, Elkin SL, et al.J Cystic Fibrosis available on-line 16th August 2011 View here
•  Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma (MesoVATS): an open-label, randomised, controlled trial. Rintoul et al. Lancet 2014 384(9948) View here
•  Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (Peacog), a randomised controlled study. Vuylsteke A, Sharples L, Charman G, Jenkins D et al.Lancet 2011 378(9800). View here
• Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea-hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure. Sharples, Quinnell et al. Health Technol Assess. 2014 Oct;18(67):1-296 View here