PTUC Publications 2022
- Five-year results of Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation. Linda D Sharples, Christine Mills, Yi-Da Chiu, Simon Fynn, Helen M Holcombe, Samer A M Nashef. European Journal of Cardio-Thoracic Surgery, 2022;, ezac181. To view this publication please click here.
- Endovascular stent grafting and open surgical replacement for chronic thoracic aortic aneurysms: a systematic review and prospective cohort study. Linda Sharples, Priya Sastry, Carol Freeman, Joanne Gray, Andrew McCarthy, Yi-Da Chiu, Colin Bicknell, Peter McMeekin, S Rao Vallabhaneni, Andrew Cook, Luke Vale & Stephen Large. Health Technology Assessment Volume: 26, Issue: 6, Published in January 2022. To view this publication click here.
PTUC Publications 2021
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Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study. Linda Sharples, Priya Sastry, Carol Freeman, Colin Bicknell, Yi-Da Chiu, Srinivasa Rao Vallabhaneni, Andrew Cook, Joanne Gray, Andrew McCarthy, Peter McMeekin, Luke Vale, Stephen Large on behalf of the ETTAA Collaborative Group. European Heart Journal, ehab784 29th November 2021. To view this publication click here.
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Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases. Javier Castillo-Olivares, David A. Wells, Matteo Ferrari, Andrew C. Y. Chan, Peter Smith, Angalee Nadesalingam, Minna Paloniemi, George W. Carnell, Luis Ohlendorf, Diego Cantoni, Martin Mayora-Neto, Phil Palmer, Paul Tonks, Nigel J. Temperton, David Peterhoff, Patrick Neckermann, Ralf Wagner, Rainer Doffinger, Sarah Kempster, Ashley D. Otter, Amanda Semper, Tim Brooks, Anna Albecka, Leo C. James, Mark Page, Wilhelm Schwaeble, Helen Baxendale and Jonathan L. Heeney. Frontiers in Immunology. 19thNovember 2021. To read this publication click here.
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Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19. Helen E. Baxendale, David Wells, Jessica Gronlund, Angalee Nadesalingham, Mina Paloniemi, George Carnell, Paul Tonks, Lourdes Ceron-Gutierrez, Soraya Ebrahimi, Ashleigh Sayer, John A.G. Briggs, Xiaoli Ziong, James A Nathan, Guinevere Grice, Leo C James, Jakub Luptak, Sumita Pai, Jonathan L Heeney, Sara Lear, Rainer Doffinger. The Journal of Critical Care Medicine 2021; 7(3): 199-210. To view the publication click here
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Positioning imatinib for pulmonary arterial hypertension: A phase I/II design comprising dose finding and single-arm efficacy. Wilkins M, McKie M, Law M, Roussakis A, Harbaum L, Church C, Coghlan J, Condliffe R, Howard L, Kiely D, Lordan J, Rothman Am Suntharalingam J, Toshner M, Wort S & Villar S. Sage Journals, Pulmonary Circulation October 2021 Volume: 11 Issue: 4. To view the publication click here
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Systematic review of endovascular stent grafting versus open surgical repair for the elective treatment of arch/descending thoracic aortic aneurysms. McCarthy A, Gray J, Sastry P, et al. BMJ Open 2021;11:e043323. To view the publication click here
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Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial. Miles LF, Burt C, Arrowsmith J, McKie MA, Villar SS, Govender P, Shaylor R, Tan Z, De Silva R & Falter F. PLOS Medicine, 7 June 2021. To read the publication click here
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Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study. Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z. Cardiovascular Research, 2021;, cvab113. To view the publication click here.
PTUC Publications 2020
PTUC Publications 2019
- VOTECO2ALS: validation of tidal expired CO2 measured at home as surveillance for ventilatory failure in people with motor neurone disease (MND). Smith I, Davies M, Fofana A, et al. Thorax 2019;74:A107. View here
- Obstructive Sleep Apnea in Patients With Primary-open Angle Glaucoma: No Role for a Screening Program. Wozniak D, Bourne R, Peretz G, Willshire C, Harun S, Villar S, Chiu YD & Smith I. Journal of Glaucoma Volume 28 (8): 668 - 675, August 2019. View here
- The potential of breath analysis to improve outcome for patients with lung cancer. Antoniou SX, Gaude E, Ruparel M, van der Schee MP, Janes SM, Rintoul RC & The LuCID Group. Journal of Breath Research Volume 13, Issue 13: 24 April 2019. View here
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The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial. Giblett JP, Clarke S, Zhao T, McCormick LM, Braganza DM, Denem CG, O'Sullivan M, Adlam D, Clarke SC, Steele J, Fielding S, West NEJ, Villar SS & Hoole SP. American Heart Journal Volume: 215, 9 June 2019. View here
PTUC Publications 2018
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Mini-Stern Trial: A randomized trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement. Nair SK, Sudarshan CD, Thorpe BS, Singh J, Pillay T, Catarino P, Valchanov K, Codispoti M, Dunning J, Abu-Omar Y, Moorjani N, Matthews C, Freeman CJ, Fox-Rushby JA & Sharples LD. The Journal of Thoracic and Cardiovascular Surgery Volume 156, Issue 6: December 2018 View here
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Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation. Sharples L, Everett C, Singh J, Mills C, Spyt T, Abu-Omar Y, et al. Health Technol Assess 2018;22(19). View the article here.
- Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation. Sharples L, Everett C, Singh J, Mills C, Spyt T, Abu-Omar Y, Fynn S, Thorpe B, Stoneman V, Goddard H, Fox-Rushby J & Nashef S. Health Technology Assessment Volume: 22, Issue: 19, April 2018 View here
- Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation. Nashef S, Fynn S, Abu-Omar Y, Spyt T, Mills C, Everett C, Fox-Rushby J, Singh J, Dalrymple-Hay M, Sudarshan C, Codispoti M, Braidley P, Wells F & Sharples L. European Journal of Cardio-Thoracic Surgery, Volume 54, Issue 4, October 2018, Pages 729–737. View the article here.
PTUC Publications 2017
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Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study. Hoole S P, Hernández-Sánchez J, Davies W R, McNab D C, Calvert P A, Rana B S, Shapiro L M & Davies M G. Canadian Journal of Cardiology, December 2017, 33,12 (1708-1715). View here
- Recovery of Left Atrial Contractile Function After Maze Surgery in Persistent Longstanding Atrial Fibrillation. Yasir Abu-Omar, Samar Nashef et al. JACC 7, 16, Oct.2017. View here
- Clinical trial protocol for TRANSFORM-UK: A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertension. Jules Hernandez-Sanchez, Louise Harlow, Mark Toshner et al. Pulmonary Circulation, 28 Sep 2017. View here
PTUC Publications 2014 - 2016
- The ETTAA study protocol: a UK-wide observational study of 'Effective Treatments for Thoracic Aortic Aneurysm'. Sastry, P., Hughes, V., Hayes, P., Vallabhaneni, S., Sharples, L., Thompson, M., Catarino, P., Moorjani, N., Vale, L., Gray, J., Cook, A., Elefteriades, J. A. & Large, S. R. 2015BMJ Open, 5, e008147.. BMJ Open. 2015 Jun 2;5(6) View here
- Cost-effectiveness of initial stress cardiovascular MR, stress SPECT or stress echocardiography as a gate-keeper test, compared with upfront invasive coronary angiography in the investigation and management of patients with stable chest pain: mid-term outcomes from the CECaT randomised controlled trial. Crean A et al. BMJ Open. 2014 Feb 7;4(2) View here
- Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma (MesoVATS): an open-label, randomised, controlled trial. Rintoul et al. Lancet 2014 384(9948) View here
- Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea-hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure. Sharples, Quinnell et al. Health Technol Assess. 2014 Oct;18(67):1-296 View here
PTUC Publications 2013 and earlier
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Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer: results from the ASTER randomised controlled trial. Sharples, L., Jackson, C., Wheaton, E., Griffith, G., Annema, J., Dooms, C., Tourney, K., Deschepper, E., Hughes, V., Magee, L., Buxton, M. & Rintoul, R. Health Technology Assessment, 16, 1-83. 2012; 16 (18):1-83) View here
- Multicentre trial of weekly risedronate on bone density in adults with cystic fibrosis. Haworth C, Sharples L, Hughes V, Elkin SL, et al.J Cystic Fibrosis available on-line 16th August 2011 View here
- Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (Peacog), a randomised controlled study. Vuylsteke A, Sharples L, Charman G, Jenkins D et al.Lancet 2011 378(9800). View here