Dr Alain Vuylsteke is the Clinical Director of Clinical and Diagnostic Services (CADS).

He has been a Consultant in Cardiothoracic Anaesthesia and Intensive Care Medicine at Papworth since 1998, and has been Director of the National Respiratory ECMO Service at Papworth since 2011. Prior to taking on the role of Clinical Director of CADS, Dr Vuylsteke spent four years as director of the Intensive Care Unit, and four years as the Chair of the Hospital Drugs and Therapeutics Committee.

Outside Papworth, Dr Vuylsteke is an Associate Lecturer at the University of Cambridge and an examiner for the Faculty of Intensive Care Medicine. His clinical interests include Extracorporeal Membrane Oxygenation (ECMO), Pulmonary Thromboendarterectomy (PTE), and blood conservation. Other research interests include the impact of IT on healthcare.



Intensive care

Specialist Clinical Interests

Extracorporeal Membrane Oxygenation (ECMO)
Cardiothoracic Intensive Care
Pulmonary (thrombo)endarterectomy
Blood conservation techniques

Special research Interests

Perioperative cognition – Impact of IT on healthcare


Currently or formerly acting as investigator or scientific advisor for, or having received fees for consultancy from the following companies: Abbott, Adprotech, Aortech, AstraZeneca, Baxter Hemoglobin Therapeutics, CERT (China), CSL Behring, Elan Pharma, EMS Research, e-Rewards, GLG Group, Hemosol, Esai, Genzyme, Junicon, Medefield, Medicys, NovoNordisk, Pharmacia & Upjohn, Procter & Gable, Searle, The Medicines Company.

Education and Training

Bachelor of Science - BSc 1987
Doctor of Medicine - MD 1991
Certificate of Completion of Specialist Training - CCST(Anaesthesia) 1998
Diplôme d'Enseignement Spécialisé en Anésthesie at Réanimation - DESAR 1998
Fellow of the Royal College of Anaesthetists - FRCA 2004
Fellow of the Faculty of Intensive Care Medicine, FFICM 2011
Master of Arts, University of Cambridge - MA 2014

Current membership(s) of professional, national and regional bodies and university posts


Recent Publications

Publications listed on Google Scholar

Thille AW, Vuylsteke A, Bersten A.Does the Berlin definition for acute respiratory distress syndrome predict the presence of diffuse alveolar damage? Intensive Care Med. 2015 Feb;41(2):342-4. 

Parhar K, Vuylsteke A. What's new in ECMO: scoring the bad indications.
Intensive Care Med. 2014 Nov;40(11):1734-7. doi: 10.1007/s00134-014-3455-9. Epub 2014 Sep 3.

Combes A, Brodie D, Bartlett R, Brochard L, Brower R, Conrad S, De Backer D, Fan E, Ferguson N, Fortenberry J, Fraser J, Gattinoni L, Lynch W, MacLaren G, Mercat A, Mueller T, Ogino M, Peek G, Pellegrino V, Pesenti A, Ranieri M, Slutsky A, Vuylsteke A; International ECMO Network (ECMONet).Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med. 2014 Sep 1;190(5):488-96.

Giraud K, Vuylsteke A. Point-prevalence of delirium in intensive care units. Anaesthesia. 2014 Apr;69(4):394.

Borland C, Bottrill F, Jones A, Sparkes C, Vuylsteke A. The significant blood resistance to lung nitric oxide transfer lies within the red cell. J Appl Physiol (1985). 2014 Jan 1;116(1):32-41

L Whittaker, T Baglin, A Vuylsteke. Challenging the evidence for graduated compression stockings. BMJ. 2013 Jun 11;346:f3653.

C Morrison, M Jones, R Jones, A Vuylsteke. 'You can't just hit a button': an ethnographic study of strategies to repurpose data from advanced clinical information systems for clinical process improvement. BMC Med. 2013 Apr 10;11:103.

WT McBride, PS Prasad, M Armstrong, C Patterson, H Gilliland, A Drain, A Vuylsteke, R Latimer, N Khalil, A Evans, F Cambien, I Young. Cytokine phenotype, genotype, and renal outcomes at cardiac surgery.  Cytokine. 2013 Jan;61(1):275-84.

A Vuylsteke, L Sharples, G Charman, J Kneeshaw, S Tsui, J Dunning, E Wheaton, A Klein, J Arrowsmith, R Hall, D Jenkins. Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (PEACOG): a randomised controlled trial.”  Lancet. 2011 Oct 15;378(9800):1379-87.

Vuylsteke A, Vincent JL, de La Garanderie DP, Anderson FA, Emery L, Wyman A, Rushton-Smith S, Gore. Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT). JM; Euro-STAT Investigators. Crit Care. 2011;15(6):R271.

Noah MA, Peek GJ, Finney SJ, Griffiths MJ, Harrison DA, Grieve R, Sadique MZ, Sekhon JS, McAuley DF, Firmin RK, Harvey C, Cordingley JJ, Price S, Vuylsteke A, Jenkins DP, Noble DW, Bloomfield R, Walsh TS, Perkins GD, Menon D, Taylor BL, Rowan KM. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).  JAMA. 2011 Oct 19;306(15):1659-68.

R Gill, M Herbertson, A Vuylsteke, PS Olsen, C von Heymann, M Mythen, F Sellke , F Booth, TA Schmidt. Safety and efficacy of recombinant activated factor VII: a randomized placebo-controlled trial in the setting of bleeding after cardiac surgery. Circulation. 2009 Jul 7;120(1):21-7. Epub 2009 Jun 22.

Morrison C, Jones M, Blackwell A, Vuylsteke A. Electronic patient record use during ward rounds: a qualitative study of interaction between medical staff." Crit Care. 2008;12(6):R148. Epub 2008 Nov 24.

Klein AA, Nashef SA, Sharples L, Bottrill F, Dyer M, Armstrong J, Vuylsteke A. A randomized controlled trial of cell salvage in routine cardiac surgery. Anesth Analg. 2008 Nov;107(5):1487-95.

Mangano DT, Miao Y, Vuylsteke A, Tudor IC, Juneja R, Filipescu D, Hoeft A, Fontes ML, Hillel Z, Ott E, Titov T, Dietzel C, Levin J. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. Investigators of The Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation. JAMA. 2007 Feb 7;297(5):471-9.

More publications available at PubMed.

Where are we based?

Royal Papworth Hospital NHS Foundation Trust
Papworth Road
Cambridge Biomedical Campus

Telephone:  01223 638000

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