Chris Johnson is Clinical Lead for the Lung Defence and Immunology Services at Royal Papworth Hospital and Consultant to the Adult Cystic Fibrosis Unit. He is also an Honorary Consultant at Addenbrooke’s Hospital in Cambridge and a Board Member of the European Reference Network on Rare Lung disease.

The Lung Defence Clinic oversees the care of >2000 patients with bronchiectasis associated with primary and secondary immunodeficiencies, chronic Pseudomonal infection, non-tuberculous mycobacterial (NTM) lung disease, Aspergillus related lung disease, rheumatoid arthritis, serious childhood infection, chronic aspiration and primary ciliary dyskinesia.

Chris trained at the Universities of Cambridge and Oxford before completing his post-graduate training in Cambridge and undertaking a Preceptorship at Royal Papworth Hospital, the University of North Carolina at Chapel Hill and the National Jewish Hospital in Denver, USA.

He is also the Trust’s Chief Medical Information Officer with responsibility for clinical IT systems and has various national roles in IT with NHS Digital.

Specialist Clinical Interests

• Cystic Fibrosis
• Bronchiectasis
• Asthma / COPD with infection
• Complex lung infection (including Pseudomonas aeruginosa, Non Tuberculous Mycobacteria and Aspergillus)
• Primary Ciliary Dyskinesia
• Immunodeficiency

Research Interests

• Immunogenetics of airways diseases
• Genetics of non-CF bronchiectasis
• The Major Histocompatibility and Leucocyte Receptor Complexes and their role in human disease

Education and Training

• 1997 BA University of Cambridge
• 2000 BM BCh University of Oxford
• 2001 MA University of Cambridge
• 2004 MRCP UK (London)
• 2005 Wellcome Trust Clinical Research Training Fellowship
• 2012 CCST in Respiratory and General Internal Medicine
• 2012 Post CCT Clinical Fellowship in Cystic Fibrosis and Lung Infection - Papworth Hospital, University of North Carolina, National Jewish Hospital in Denver

Current membership(s) of professional, national and regional bodies and university posts

• Member, British Thoracic Society
• Member, European Respiratory Society
• Member, Royal College of Physicians of London
• Member European Cystic Fibrosis Society
• Member of steering committee, European Reference Network for Rare Lung Disease

Recent and Important Publications

Contributor to British Thoracic Society Guidelines for bronchiectasis in adults 2018

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis. Chest. 2018 May;153(5):1177-1186. doi: 10.1016/j.chest.2017.11.033. Epub 2017 Dec 13.

Chalmers J., Polverino E., Aliberti S, Johnson C (eds). Long-Term Inhaled Antibiotic Treatment in Bronchiectasis. 2018. Bronchiectasis. Springer, Cham

Management of bronchiectasis in Europe: Data from the European bronchiectasis registry (EMBARC)Charles S. Haworth, Chris Johnson, Stefano Aliberti, Pieter C. Goeminne, Felix Ringhausen, Wim Boersma, Anthony De Soyza, Marlene Murris, Eva Polverino, Montserrat Vendrell, James D. Chalmers. European Respiratory Journal  2016  48:  OA273

Bronchiectasis. 2016. Medicine.

LILRA6 copy number correlates with susceptibility to atopic dermatitis. 2016. Immunogenetics 68(9):743-7.

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families. 2016. Genes and Immunity 17(1):8-12.

Inhaled antibiotics for bronchiectasis: are we there yet? 2015. Curr Pulmonol Rep 4:198–204

The development of a website to facilitate transition from paediatric to adult CF services. 2015. Journal of Cystic Fibrosis, Vol. 14, S9

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. 2012. Genome Research, 22(10):1845-54.

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 2008. Nature Genetics, 40(6), 710-712.

Jiang W, Johnson C, Jayaraman J, Trowsdale J, Traherne JA. (2012). Extensive diversity of human innate immune genes revealed by typing for copy number variation. Genome Research, 22(10), 1845-1854.

Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L; Wellcome Trust Case Control Consortium, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J. (2008). Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics, 40(6), 710-712.

Johnson CM, Traherne JA, Jamieson SE, Tremelling M, Bingham S, Parkes M, Blackwell JM, Trowsdale J. (2007). Analysis of the BTNL2 truncating splice site mutation in tuberculosis, leprosy and Crohn’s disease. Tissue Antigens, 69(3), 236-241.