Dr Martin undertook undergraduate and clinical training at Cambridge University (Gonville and Caius College). She then completed a PhD at the University of Cambridge funded by a Medical Research Council Training Fellowship, and for this was awarded the British Cardiovascular Society Young Research Workers’ Prize. After specialist training at Papworth Hospital, she undertook clinical fellowships at two world-leading cardiac centres: Barts Heart Centre and subsequently at the Hopital du Haut-Leveque, Bordeaux, through funding from a prestigious European Society of Cardiology Training Grant.

Dr Martin treats all cardiac arrhythmias, and has a particular interest in the ablation of ventricular tachycardia and atrial fibrillation. See clairemartincardiologist.com and cardiovascular.cam.ac.uk for further details of her research interests.

Specialist Clinical Interests
  • Arrhythmias
  • Catheter ablation of ventricular tachycardia
  • Atrial tachycardia and atrial fibrillation
  • Inherited arrhythmia syndromes
Research Interests

Mechanisms and ablation strategies for ventricular tachycardia, atrial tachycardia and atrial fibrillation; mechanisms and risk stratification in inherited arrhythmia syndromes

Education and Training
  • MA Natural Sciences, University of Cambridge 2001
  • MB BChir, University of Cambridge 2004
  • MRCP, London 2007
  • PhD Cardiac Electrophysiology, University of Cambridge 2012
  • British Heart Rhythm Accreditation in Devices and Electrophysiology 2016
Current membership(s) of professional, national and regional bodies and university posts
  • Member of the Royal College of Physicians, London.
  • Member of the General Medical Council (registration number: 6110131).
  • Honorary Research Fellow, University College London and Bordeaux University
  • Member of British Heart Rhythm Society
  • Member of British Cardiac Society
  • Member of European Society of Cardiology
Recent and Important Publications

Book chapters

1.    Martin CA and Lambiase PD (2018). Atrial fibrillation and progressive cardiac conduction disease. In: Cardiovascular Genetics and Genomics for Clinicians.  Eds. Kumar D; Elliott, P DOI 10.1007/978-3-319-66114-8_15

Original research articles

1.       Martin R, Maury P, Bisceglia C, Wong T, Estner H, Meyer C, Dallet C, Martin CA, Shi R, Takigawa M, Rollin A,  Frontera A, Thompson N, Kitamura T, Vlachos K, Wolf M, Duchâteau J, Massoulié G, Pambrun T, Denis A, Derval N, Hocini M, Della Bella P, Haïssaguerre M, Jaïs P, Dubois R, Sacher F. Characteristics of scar related ventricular tachycardia circuits using ultra-high density mapping: A multi-center study. In press. Circ AE

2.       Asvestas D, Vlachos K, Bazoukis G, Martin CA, Letsas KP, Sakellaropoulou A, Saplaouras A, Tirovolas K, Prappa E, Vassilikos V, Kalokathis A-M, Valkanas K, Sideris A, Efremidis M. (2018). Left atrial voltage mapping using a new impedance-based algorithm in patients with paroxysmal atrial fibrillation. In press. PACE.

3.       Bourier F, Duchateau J, Vlachos K, Lam A, Martin CA, Takigawa M, Kitamura T, Frontera A, Cheniti G, Pambrun T, Klotz N, Denis A, Derval N, Cochet H, Sacher F, Hocini M, Haïssaguerre M, Jais P.

High power short duration vs. standard RF ablation: Insights on lesion metrics. J Cardiovasc Electrophysiol. 2018 doi: 10.1111/jce.13724

4.       Takigawa M, Derval N, Maury P, Martin R, Miyazaki S, Yamashita S, Frontera A, Vlachos K, Kitamura T, Cheniti G, Massouille G, Thompson N, Martin CA, Wolf M, Pillois X, Duchateau C, Klotz N, Duparc A, Rollin A, Pambrun T, Denis A, Sacher F, Cochet H, Hocini M, Haissaguerre M, Jaïs P. (2018) A comprehensive multi-center study of the common isthmus in post AF ablation multiple-loop atrial Tachycardia. Circ AE. 2018 Jun;11(6):e006019. doi: 10.1161/CIRCEP.117.006019.

5.       Takigawa M, Relan J, Martin R, Kim S, Kitamura T, Frontera A, Cheniti G, Vlachos K, Massoullié G, Martin CA, Thompson N, Wolf M, Bourier F, Lam A, Duchateau J, Klotz N, Pambrun T, Denis A, Derval N, Magat J, Naulin J, Merle M, Collot F, Quesson B, Cochet H, Hocini M, Haïssaguerre M, Sacher F, Jaïs P. The Importance of Bipolar Electrode Orientation on Local Electrogram Properties. Heart Rhythm. 2018 doi: 10.1016/j.hrthm.2018.07.020.

6.       Martin CA, Martin R, Maury P, Takigawa M, Kitamura T, Frontera A, Cheniti G, Duchateau J, Vlachos K, Bourier F, Lam A, Gajendragadkar P, Lord S; Murray S, Shephard E, Pambrun T, Denis A, Derval N, Jais P, Hocini M, Haissaguerre M, Sacher F. First clinical use of novel ablation catheter incorporating local impedance data. 2018.  J Cardiovasc Electrophysiol. 2018. doi: 10.1111/jce.13654.

7.       Takigawa M, Takahashi A, Tanaka Y, Martin CA, Nakashima E, Yamao K, Sagawa Y, Kuwahara T, Okubo K, Takahashi Y, Watari Y, Nakajima J, Takagi K, Fujino T, Kimura S, Hikita H, Hirao K. Simple and novel technique to confirm complete mitral isthmus block. J Cardiovasc Electrophysiol. 2018 doi: 10.1111/jce.13700.

8.       Martin CA*, Orini M*, Srinivasan N, Bhar-Amato J, Honarbakhsh S, Chow A, Lowe MD, Simon RD, Elliott PM, Taggart P, Lambiase PD (2018). Novel repolarisation metric predicts arrhythmia origin and clinical events in ARVC and Brugada Syndrome. In press. International Journal of Cardiology. doi.org/10.1016/j.ijcard.2018.05.063 (*equal contributors)

9.       Martin CA, Curtain JP, Gajendragadkar PR, Begley DA, Fynn SP, Grace AA, Heck PM, Virdee MS, Agarwal S (2018). Ablation of complex fractionated electrograms improves outcome in long standing persistent AF. J Atr Fibrillation. 2018. doi: 10.4022/jafib.160

10.   Ciobotaru V, Combes N, Martin CA, Marijon E, Bruguière E, Maupas E, Borton A, Boulenc J-M, Thambo J-B, Teiger E, Pujadas-Berthault P, Ternacle J, Iriart X (2018). Left atrial appendage occlusion simulation based on three-dimensional printing: New insights in outcome and technique. EuroIntervention. 2018 Mar 13. pii: EIJ-D-17-00970. doi: 10.4244/EIJ-D-17-00970

11.   Wolf M, Sacher F, Cochet H., Kitamura T, Takigawa M, Yamashita S, Vlachos K, Cheniti G, Frontera A, Martin R, Thompson N, Massouille G, Lam A, Martin CA, Collot F, Duchateau J, Pambrun T, Denis A, Derval N, Hocini M, Haissaguerre M, Jaïs P. (2018) Long-term Outcome of Substrate Modification in Ablation of Post-Myocardial Infarction Ventricular Tachycardia. Circ AE. Circ Arrhythm Electrophysiol. 2018 Feb;11(2):e005635. doi: 10.1161/CIRCEP.117.005635.

12.   Kitamura T, Martin R, Denis A, Takigawa M, Duparc A, Rollin A, Frontera A, Thompson N, Massouille G, Cheniti G, Wolf M, Vlachos K, Martin CA, Al Jefairi N, Klotz N, Duchateau J, Pambrun T, Cochet H, Sacher F, Hocini M, Haissaguerre M, Maury P, Jaïs P, Derval N. (2018) Characteristics of single loop macroreentrant biatrial tachycardia diagnosed by ultra-high resolution mapping system. Circ AE. 2018 Feb;11(2):e005558. doi: 10.1161/CIRCEP.117.005558.

13.   Takigawa M, Derval N, Frontera A, Martin R, Yamashita S, Cheniti G, Vlachos K, Thompson N, Kitamura T, Wolf M, Massoullie G, Martin C, Al-Jefairi N, Amraoui S, Duchateau J, Klotz N, Pambrun T, Denis A, Sacher F, Cochet H, Hocini M, Haissaguerre M, Jais P. Re-visiting anatomical macroreentrant tachycardia after atrial fibrillation ablation using ultra-high-resolution mapping: implications for ablation. Heart Rhythm. 2017 Oct 25. pii: S1547-5271(17)31243-2. doi: 10.1016/j.hrthm.2017.10.029. 

14.   Denis ASacher FDerval NMartin RLim HSPambrun TMassoullie GDuchateau JCochet HPillois XCheniti GFrontera ATakigawa MVlachos KMartin C, Kitamura THocini MDouard HJaïs PHaïssaguerre M. Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients. Europace. 2018 Feb 1. doi: 10.1093/europace/euy007.

15.   Zhao TX, Martin CA, Cooper JP, Gajendragadkar PR (2017). Coarse fibrillatory waves in atrial fibrillation predict success of electrical cardioversion. Ann Noninvasive Electrocardiol. 2017 Dec 22. doi: 10.1111/anec.12528

16.   Sacher F, Jésel L, Borni-Duval C, De Precigout V, Lavainne F, Bourdenx J-P, Haddj-Elmrabet A, Seigneuric B, Keller A, Ott J, Savel H, Delmas Y, Bazin-kara D, Klotz N, Ploux S, Buffler S, Ritter P, Rondeau V, Bordachar P, Martin CA, Deplagne A, Reuter S, Haissaguerre M, Gourraud J-B, Vigneau C, Mabo P, Maury P, Hannedouche T, Benard A, Combe C (2017). Long term rhythm monitoring in Hemodialysis patients /Implantable Loop Recorder in Hemodialysis Patients: The RYTHMODIAL study. JACC EP DOI: 10.1016/j.jacep.2017.08.002

17.   Honarbakhsh S, Schilling RJ, Providência R, Dhillon G, Martin CA, Sawhney V, Keating E, Finlay M, Ahsan S, Chow A, Earley MJ, Hunter R (2017). Panoramic atrial mapping with basket catheters: a quantitative analysis to optimize practice, patient selection and catheter choice.  J Cardiovasc Electrophysiol. 2017 Sep 1. doi: 10.1111/jce.13331.

18.   Martin CA, Curtain JP, Gajendragadkar PR, Begley DA, Fynn SP, Grace AA, Heck PM, Salaunkey K, Virdee MS, Agarwal S (2017). Improved outcome and cost effectiveness in ablation of persistent atrial fibrillation under general anaesthetic. Europace. https://doi.org/10.1093/europace/eux057

19.   Chana HS, Martin CA, Cakebread HE, Adjei FD, Gajendragadkar PR. (2015) Diagnostic accuracy of cardiothoracic ratio on admission chest radiography to detect left or right ventricular systolic dysfunction: a retrospective study. Journal of the Royal Society of Medicine. doi: 10.1177/0141076815588314

20.   Gajendragadkar PR, Moualed DJ, Nicolson PL, Adjei FD, Cakebread HE, Duehmke RM, Martin CA. (2013) The survival time of chocolates on hospital wards: covert observational study. BMJ. 14;347:f7198. doi: 10.1136/bmj.f7198

(Most read BMJ paper ever with over 500,000 views; 6th greatest public engagement in 2014 - http://www.altmetric.com/top100/2014/)

21.   Gajendragadkar PR, Moualed DJ, Nicolson PL, Adjei FD, Cakebread HE, Duehmke RM, Martin CA. (2014). Authors' reply to Vinden. BMJ. 348:g328. doi: 10.1136/bmj.g328

22.   Martin CA, Siedlecka U, Kemmerich K, Lawrence J, Cartledge J, Guzadhur L, Brice N, Grace AA, Schwiening C, Terracciano CM & Huang CL. (2012). Reduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice. Open Biol  2,120072. doi: 10.1098/rsob.120072

23.   Martin CA, Huang CL, Grace AA (2011). Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model. Am J Physiol Heart Circ Physiol; 300(2):H605-16. doi: 10.1152/ajpheart.00824.2010

24.   Martin CA, Guzadhur L, Grace AA, Lei M, Huang CL (2011) Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. Am J Physiol Heart Circ Physiol; 300(5):H1853-62.  doi: 10.1152/ajpheart.00034.2011

25.   Martin CA, Huang CL, Grace AA (2011) Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a (+/-) mouse model. Pflugers Arch; 462(4):495-504. doi: 10.1007/s00424-011-0989-3

26.   Martin CA, Zhang Y, Grace AA, Huang CL (2010) In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities. Journal of Electrocardiology;43(5):433-9.  doi: 10.1016/j.jelectrocard.2010.05.015

27.   Martin CA, Zhang Y, Grace AA, Huang CL (2010) Increased Right Ventricular Repolarization Gradients Promote Arrhythmogenesis in a Murine Model of Brugada Syndrome. J Cardiovasc Electrophysiol.; 21(10):1153-9. doi: 10.1111/j.1540-8167.2010.01767.x.

28.   Matthews GDK*, Martin CA*, Zhang Y, Grace AA, Huang CL (2010) Regional variations in action potential alternans in isolated murine Scn5a+/- hearts during dynamic pacing. Acta Physiol (Oxf), 200(2):129-46. (*equal contributors)

29.   Martin CA, Petousi N, Chawla S, Hockaday AR, Burgess AJ, Fraser JA, Huang CL, Skepper JN.(2003) The effect of extracellular tonicity on the anatomy of triad complexes in amphibian skeletal muscle. J Muscle Res Cell Motil; 24(7):407-15.

Review articles

1.       Iriart X, Ciobotaru V, Martin CA, Cochet H, Jalal Z, Thambo J-B, Quessard A. Role of cardiac imaging and 3D printing in percutaneous appendage closure. Archives of Cardiovascular Diseases. 2018 doi: 10.1016/j.acvd.2018.04.005

2.       Frontera A, Cheniti G, Martin CA, Takigawa M, Pujo S, Martin R, Thompson N, Kitamura T, Vlachos K, Wolf M, Al-Jefairi N, Massouille G, Duchateau C, Pambrun T, Denis A, Sacher F, Derval N, Jaïs P, Hocini M, Haissaguerre M (2017) Frontiers in non-invasive cardiac mapping: future implications for arrhythmia treatment Minerva Cardioangiol. doi: 10.23736/S0026-4725.17.04463-2. 

3.       Martin CA and Lambiase PD (2016). Pathophysiology, diagnosis and treatment of tachycardiomyopathy. Heart. 2017 Aug 30. pii: heartjnl-2016-310391. doi: 10.1136/heartjnl-2016-310391

4.       Martin CA, Huang CL, Matthews GD (2013) The role of ion channelopathies in sudden cardiac death: implications for clinical practice. Ann Med; 45(4):364. doi: 10.3109/07853890.2013.783994

5.       Martin CA, Matthews GDK, Huang CL (2012) Sudden Cardiac Death and Inherited Channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease. Heart; 98(7):536-43. doi: 10.1136/heartjnl-2011-300953

6.       Martin CA, Huang CL, Matthews GDK (2011) Recent developments in the management of patients at risk for sudden cardiac death. Postgrad Med; 123(2):84-94.  doi: 10.3810/pgm.2011.03.2266

7.       Martin CA, Huang CL, Grace AA (2010) Progressive Conduction Disorders. Cardiac Electrophysiology Clinics; 2(4):509-519



1.       Martin CA, Sacher F (2018) Extra-Stimulus Pacing: The Key to Targeting Critical Substrate in VT Ablation? JACC: Clinical Electrophysiology Volume 4, Issue 3. DOI: 10.1016/j.jacep.2018.02.004.