Dr Baxendale joined the Clinical Immunology Department at Royal Papworth Hospital NHS Foundation Trust in February 2011. She is based in the Centre for Lung Infection (incorporating The Adult Cystic Fibrosis Centre, The Lung Defence Clinic and The Immunology Clinic) where she provides the clinical immunology service for investigation and management of patients with recurrent lung infection and immunodeficiency. She also holds an Honorary Consultant contract at Addenbrooke’s Hospital where she provides the Paediatric Immunology service and works closely with clinicians providing the adult immunology service. Dr Baxendale holds an Honorary academic position at the University of Cambridge.

Previously she worked as a Senior Lecturer in Clinical Immunology at University College London (UCL) and prior to this was a Clinician Scientist at the UCL Institute of Child Health.

Specialist Clinical Interests

Investigation and management of primary and secondary immunodeficiency in children and adults. Immune development; Pneumococcal disease; Transitional care for young people with primary immunodeficiency.

Research Interests

B cell lineage and repertoire development; Natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease. Role of Immunoglobulin replacement therapy in treatment of patients with recurrent lung infection.

Education and Training

Bsc(Hons) Immunology
PhD Immunobiology.

Current membership(s) of professional, national and regional bodies and university posts:

Royal College of Paediatrics and Child Health
Immunology Representative for the RCP Young Adults and Adolescence Steering Group
British Society of Immunology
European Society of Immunodeficiencies
UKPrimary Immunodefiency Network
Member of the General Medical Council

Recent and Important Publications

Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia). The United Kingdom Primary Immune Deficiency (UKPID) registry 2012 to 2017. Clin Exp Immunol. 2018. Jun;192(3):284-291.

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies.  Front Immunol. 2018 Mar 16;9:543

Loss-of-function nuclear factor κB subunit 1 (NFKB1)variants are the most common monogenic cause of common variable immunodeficiency in Europeans. J Allergy Clin Immunol. 2018 Oct;142(4):1285-1296. 

United Kingdom Primary Immunodeficiency Network(UKPIN) Immunoglobulin Decision to Treat Study Group. Prescribing Immunoglobulin Replacement Therapy for Patients with Non-classical and Secondary AntibodyDeficiency: an Analysis of the Practice of Clinical Immunologists in the UK and Republic of Ireland. J Clin Immunol. 2018 Feb;38(2):204-213.

Gräf S, Morrell NW. UK NationalCohort Study of Idiopathic and Heritable PAH, Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of PatientsDiagnosed Clinically With Pulmonary Arterial Hypertension. Circulation. 2017 Nov 21;136(21):2022-2033. 

Hurst JR et al. British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. J Allergy Clin Immunol Pract. 2017 Mar 25. pii: S2213-2198(17)30035-1. PMID: 28351785

Hou TZ et al. Blood. Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. 2017 Mar 16;129(11):1458-1468. doi: 

Wilson R et al. Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens. PLoS Pathog. 2017 Jan 30;13(1):e1006137. doi: 10.1371/journal.ppat.1006137. Wilson R et al. Correction: Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens. PLoS Pathog. 2017 Mar 8;13(3):e1006259. doi: 10.1371/journal.ppat.1006259. eCollection 2017 Mar. PMID:28273179

Smith SP, Baxendale HE, Sterling JC. Clearance of recalcitrant warts in a patient with idiopathic immune deficiency following administration of the quadrivalent human papillomavirus vaccine. Clin Exp Dermatol. 2017 Apr;42(3):306-308. doi: 10.1111/ced.13038. 

Carss KJ et al. Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. Am J Hum Genet. 2017 Jan 5;100(1):75-90. doi: 10.1016/j.ajhg.2016.12.003. 

Varma R, Campbell G, Baxendale H. Lesson of the month 1: Autoinflammatory syndromes - an unusual cause of pyrexia of unknown origin. Clin Med (Lond). 2016 Oct;16(5):488-490. 

Coulter TI et al. Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study. J Allergy Clin Immunol. 2017 Feb;139(2):597-606.e4. 

Eisen S, et al. B-cell development and pneumococcal immunity in vertically acquired HIV infection. AIDS. 2016 Jul 31;30(12):1867-76. doi: 10.1097

Brent J et al. Clinical and laboratory correlates of lung disease and cancer in adults with idiopathic  hypogammaglobulinaemia. Clin Exp Immunol. 2016 Apr;184(1):73-82. doi: 

Holmes SN, Condliffe A, Griffiths W, Baxendale H, Kumararatne DS. Familial hepatopulmonary syndrome in common variable immunodeficiency. J Clin Immunol. 2015 Apr;35(3):302-4. doi: 10.1007/s10875-015-0142-8.

Turley AJ et al. Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe. J Clin Immunol. 2015 Feb;35(2):199-205. doi: 10.1007/s10875-015-0137-5. 

Grimbacher B; The European Society for Immunodeficiencies (ESID) registry 2014. ESID Registry Working Party. Clin Exp Immunol. 2014 Dec;178 Suppl 1:18-20. doi: 10.

Wilson R et al. Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses. Mucosal Immunol. 2015 May;8(3):627-39. doi: 10.1038/mi.2014.95.