Dr Toshner is a chest physician specialising in pulmonary vascular disorders. He holds an honorary contract at Addenbrooke’s Hospital and is a Visiting Scientist at the University of Cambridge where he works closely with Professor Nicholas Morrell. Prior to taking up his consultant post he held a Clinical Lecturer’s post in Translational Medicine at the University of Cambridge and is interested in taking basic science and applying it to the clinical arena for patient benefit.
He is an active member of the British Thoracic Society formerly sitting on the General Council as the specialist trainee representative, the Education and Training Committee and currently the Specialist Advisory Group for Pulmonary Vascular Diseases. He retains an interest in teaching and has in the past acted as the Collector of Cases for the University, contributed to the East Anglian Specialist Advisory Committee, the Eastern Deanery Specialist Training Committee and organised the programme for Eastern Deanery specialist registrar training. He is an associate editor for BMC Cardiovascular Disorders.
Toshner M, Dunmore BJ, McKinney EF, Southwood M, Caruso P, Upton PD, Waters JP, Ormiston ML, Skepper JN, Nash G, Rana AA, Morrell NW. Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells. PLoS One. 2014 Mar 20;9(3):e91334.
Mackenzie Ross RV, Toshner M, Soon E, Naeije R, Pepke-Zaba J. Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jul;305(2):H259-64
Dunmore BJ, Drake KM, Upton PD, Toshner M, Aldred MA, Morrell NW. The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations. Hum Mol Genet. 2013 Sep 15;22(18):3667-79.
Geti I, Ormiston ML, Rouhani F, Toshner M, Movassagh M, Nichols J, Mansfield W, Southwood M, Bradley A, Rana AA, Vallier L, Morrell NW. A practical and efficient cellular substrate for the generation of induced pluripotent stem cells from adults: blood-derived endothelial progenitor cells. Stem Cells. Trans Med. 2012 Dec;1(12):855-65
Ormiston ML, Chang C, Long LL, Soon E, Jones D, Machado R, Treacy C, Toshner M, Campbell K, Riding A, Southwood M, Pepke-Zaba J, Exley A, Trembath RC, Colucci F, Wills M, Trowsdale J, Morrell NW. Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation. 2012 Aug 28;126(9):1099-109
Toshner M, Suntharalingam J, Fesler P, Soon E, Sheares KK, Jenkins D, White P, Morrell NW, Naeije R, Pepke-Zaba J. Occlusion pressure analysis role in partitioning of pulmonary vascular resistance in CTEPH. Eur Respir J. 2012 Sep;40(3):612-7
Soon E, Toshner M, Mela M, Grace A, Sheares K, Morrell N, Pepke-Zaba J. Risk of potentially life-threatening thyroid dysfunction due to amiodarone in idiopathic pulmonary arterial hypertension patients. J Am Coll Cardiol. 2011 Feb 22;57(8):997-8
Soon E, Treacy CM, Toshner M, MacKenzie-Ross R, Manglam V, Busbridge M, Sinclair-McGarvie M, Arnold J, Sheares KK, Morrell NW, Pepke-Zaba J. Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension. Thorax. 2011 Apr;66(4):326-32
Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock AJ, Barst RJ, Shapiro S, Golpon H, Toshner M, Grimminger F, Pascoe S. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med. 2010 1;182(9):1171-7
Toshner M, Gopalan D, Suntharalingam J, Treacy C, Soon E, Sheares KK, Morrell NW, Screaton N, Pepke-Zaba J. Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant. 2010 Jun;29(6):610-5
Toshner M, Voswinckel R, Southwood M, Al-Lamki R, Howard LS, Marchesan D, Yang J, Suntharalingam J, Soon E, Exley A, Stewart S, Hecker M, Zhu Z, Gehling U, Seeger W, Pepke-Zaba J, Morrell NW. Evidence for dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2009 Oct 15;180(8):780-7