Dr Hoole qualified in medicine with distinction from University of Oxford, and subsequently trained in cardiology in London and Cambridge. He was appointed as a consultant interventional cardiologist in September 2011 and currently holds a national clinical excellence Silver award.
He has published over 160 peer reviewed manuscripts, several books/ book chapters and is an affiliated Associate Professor at the University of Cambridge. He is a specialist adviser to MHRA interventional device program, NICE interventional procedures program and the NIHR HTA program. He is an Expert Adviser for the NICE Centre for Guidelines and previous guideline Chair.
He has participated in guideline and position paper publications for the ESC, ACC, AHA and NICE. Dr Hoole is currently appointed as a NICE TA and HST Appeal panel member and is the GIRFT Cardiology joint national lead at NHS England. He is regularly asked to act as a medicolegal expert and has an efficient and busy private practice.
Dr Hoole is happy to see adult self funding or insured private patients with any cardiological problem but he has a specialist interest in relieving patients of angina and in particular, performing complex coronary intervention and stenting via the wrist artery. This includes the treatment of chronic total occlusions, left main, bifurcation and heavily calcified lesions with calcium modification techniques including laser. He is an expert on stent safety and improving stent outcomes by utilising coronary physiology and advanced coronary imaging.
He specialises in treating refractory angina and leads the regional coronary sinus reducer and coronary microvascular angina services. He is also the national interventional lead for the UK balloon pulmonary angioplasty service.
Coronary Intervention, chronic total occlusion PCI, Calcium modification with RA, OA and ELCA, Structural Intervention, Coronary Sinus Reducer, Interventional Research, CT coronary angiography, cardiac support devices and balloon pulmonary angioplasty for CTEPH
Coronary stent safety
Cardioprotection during PCI
Metabolic optimisation during PCI
Myocardial injury during revascularization
Coronary/left ventricular physiological assessment during PCI
Coronary microvascular and collateral function assessment during PCI
Vulnerable plaque imaging with VH-IVUS and OCT
Biomarker profiling during PCI
Coronary intervention risk prediction modeling
Coronary stent design & technology
Innovation of interventional devices
PFO closure in sleep apneoa
Right ventricular haemodynamics
1995 BA (Class: I), University of Oxford
1998 BM BCh, University of Oxford
2001 MRCP, London
2001 MA, University of Oxford
2009 DM, University of Oxford
2010 Board Certified CCT, USA
2015 FESC
2015 FACC
2016 FRCP, London
Fellow of the Royal College of Physicians, London
Fellow of the American College of Cardiology
Fellow of the European Society of Cardiology
British Cardiovascular Intervention Society
General Medical Council (Full registration: 4530426)
Specialist Advisor to National Institute for Health and Clinical Excellence
Specialist Advisor to NIHR HTA Programme
Specialist Adviser to MHRA Interventional Devices Programme
Member of NICE NCGC Acute Chest Pain Guideline Committee, RCP
Member of Regional Specialist Training Committee (Cardiology), Eastern Deanery
NICE Clinical Guideline Chair
Elected Member of Early Career Section Leadership Council, ACC
To view Dr Hoole's clinical outcomes, please click on this link. This will take you to the British Cardiovascular Intervention Society website which is not part of the Royal Papworth Hospital website.
Short communication: Endothelin-1 in cardiac allograft vasculopathy
Abraham GR, Davenport AP, Hoole SP Microvascular Research 2024 in press
Worldwide CTEPH Registry: Long-term outcomes with Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty and Medical Therapy
Delcroix M, Pepke-Zaba J, D'Armini A, Fadel E, Guth S, Hoole SP, Jenkins DP, Kiely D, Kim N, Madani M, Matsubara H, Nakayama K, Ogawa A, Ota-Arakaki J, Quarck R, Sadushi-Kolici R, Simonneau G, Wiedenroth C, Yildızeli B, Mayer E, Lang I. Circulation 2024 in press
Evaluation of Microcirculatory Protection In percutaneous REvascularisation: a stent implantation technique and device comparison.
Aetesam-ur-Rahman M, Zhao TX, Paques K, Oliveira J, Duckworth M, Khialani B, Kyranis S, Bennett MR, West NEJ, Hoole SP. Catheterization and Cardiovascular Interventions 2024 in press
Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial.
Morrow A, Young R, Abraham G, Hoole SP, Greenwood J, El Shibly M, Arnold R, Shanmuganathan M, Ferreira V, Rakhit R, Galasko G, Sinha A, Perera D, Al-Lamee R, Spyridopoulos I, Kotecha A, Clesham G, Ford T, Davenport A, Padmanabhan S, Jolly L, Kellman P, Kaski JC, Weir R, Sattar N, Kennedy J, Macfarlane P, Welsh P, McConnachie A, Berry C. Circulation 2024 in press
Correcting Common OCT Artifacts Enhances Plaque Classification and Identification of Higher-Risk Plaque Features.
Jessney B, Chen X, Gu S, Brown AJ, Obaid D, Costopoulos C, Goddard M, Garcia Garcia HM, Serruys P, Onuma YO, Roberts M, Shah N, Hoole SP, Bennett MR CRM 2024 in press
Comparing pressure-bounded versus thermodilution-derived coronary flow reserve in unobstructed coronary arteries.
Ang DTY, Abraham G, Sim KYT, Sidik NP, Anwar M, Ford TJ, Berry C, Hoole SP. Am J Cardiol 2024 in press.
Differences in quantitative myocardial perfusion mapping by CMR at 1.5T and 3T.
Abraham GR, Berry C, Hoole SP, Weir McCall JR. AHJ Plus: Cardiology Research and Practice 2024 in press
Prognostic value of stress perfusion cardiac magnetic resonance in cardiovascular disease: A systematic review and meta-analysis of the effects of the scanner, stress agent and analysis technique.
Fu Q, Alabed S, Hoole SP, Abraham G, Weir-McCall JR. Radiology: Cardiothoracic Imaging 2024 in press
CT pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation.
Wall C, Weir-McCall J, Tweed K, Hoole SP, Gopalan D, Huang Y, Corovic A, Peverelli M, Dey D, Bennett MR, Rudd JHF, Kydd A, Bhagra S, Tarkin JM. EHJ CV Imaging 2024 in press
Complex PCI in Patients Unable to Undergo CABG during the COVID-19 Pandemic.
Kite T, Chase A, Owens C, Shaukat A, Mozid A, O’Kane P, Routledge H, Perera D, Jain A, Palmer N, Hoole SP, Egred M, Sinha T, Ananthram B, Byrne J, Morris P, Kean S, Sabra A, Aetesam-ur-Rahman M, Mailey J, Abdalwahab A, Terentes-Printzios, Kanyal R, Curzen N, Berry C, Gershlick AH, Ladwiniec A. J Invasive Cardiol. 2024 in press
Prognostic Value of Microvascular Resistance Reserve After Primary Percutaneous Coronary Intervention: a Pooled Analysis of Individual Patient Data.
Eerdekens1 R, El Farissi1 M, De Maria GL, van Royen N, van Leeuwen MAH, Hoole SP, Marin F, Tonino PAL, Pijls NHJ, Fineschi M, Oldroyd KG, Berry C, Banning AP, Fearon WF, Zimmermann FM. JACC 2024 in press
Percutaneous Left Ventricular Unloading During High-Risk Coronary Intervention: Rationale and Design of the CHIP-BCIS3 Randomized Controlled Trial.
Ryan M, Ezad SM, Webb I, O’Kane PD, Dodd M, Evans R, Laidlaw L, Khan S, Weerackody R, Bagnall A, Panoulas V, Rahman H, Strange JW, Fath-Ordoubadi F, Hoole SP, Stables RH, Curzen N, Clayton T and Perera D* on behalf of the CHIP-BCIS3 Investigators. Circulation Cardiov Inv 2024 in pres
Prognostic Value of The Index of Microcirculatory Resistance After Primary Percutaneous Coronary Intervention: a Pooled Analysis of Individual Patient Data from 6 cohorts.
El Farissi M, Zimmermann FM, De Maria GL, van Royen N, van Leeuwen MAH, Carrick D, Carberry J, Wijnbergen IF, Konijnenberg L, Hoole SP, Fineschi M, Pijls NHJ, Oldroyd KG, Banning AP, Berry C, Fearon WF. JACC Intv 2023 in press
Balloon pulmonary angioplasty outcomes in patients previously treated by pulmonary endarterectomy surgery are inferior to those of inoperable patients.
Kirkby LC, Rodgers MS, Amaral-Almeida L, Sheares K, Toshner M, Taboada D, Ng C, Cannon JE, Tsui S, Taghavi FJ, Jenkins DP, Coghlan JG, Pepke-Zaba J, Hoole SP. Pulmonary Circulation 2023 in press
Long-Term Durability of Self-Expanding and Balloon-Expandable Transcatheter Aortic Valve Prostheses: UK TAVI Registry
Ali N, Hildick-Smith D, Parker J, Malkin CJ, Cunnington MS, Gurung S, Mailey J, MacCarthy PA, Bharucha A, Brecker SJ, Hoole SP, Dorman S, Doshi SN, Wiper A, Buch MH, Banning AP, Spence MS, Blackman DJ. Catheterization and Cardiovascular Interventions 2023; 101(5):932-942.
Acute lung injury after balloon pulmonary angioplasty results in a similar haemodynamic response and possible clinical advantage at follow-up.
Rodgers MS, Kirkby LC, Amaral-Almeida L, Sheares K, Toshner M, Taboada D, Ng C, Cannon JE, D’Errico L, Ruggiero A, Screaton N, Jenkins DP, Coghlan JG, Pepke-Zaba J, Hoole SP Pulmonary Circulation 2022 12(4):e12166
Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Per-Protocol Analysis of the GLOBAL LEADERS Trial.
Gragnano F, Zwahlen M, Vranckx P, Heg D, Schmidlin K, Hamm C, Steg PG, Gargiulo G, McFadden EP, Onuma Y, Chichareon P, Benit E, Möllmann H, Janssens L, Leonardi S, Zurakowski A, Arrivi A, Van Geuns RJ, Huber K, Slagboom T, Calabrò P, Serruys PW, Jüni P, Valgimigli M, Windecker S and GLOBAL LEADERS Investigators. J Am Heart Assoc. 2022 May 17;11(10):e024291. doi: 10.1161/JAHA.121.024291.
Interobserver variability between expert, experienced and novice operators affects interpretation of Optical Coherence Tomography & 20Mhz Intravascular Ultrasound imaging.
Martin W, McNaughton E, Bambrough P, West NEJW, Hoole SP. CRM 2023 47 (2023): 33-39.
Somatostatin receptor 2 PET/MR imaging of inflammatory disease activity in large vessel vasculitis and atherosclerosis.
Corovic A, Wall C, Chimeno MN, Huang Y, Gopalan D, Imaz M, Zulcinski M, Peverelli M, Lambert J, Bressan D, Maughan RT, Pericleous C, Jordan N, Hoole SP, Calvert PA, Dean A, Rassl D, Iles M, Hannon G, Frontini M, Manavaki R, Fryer T, Aloji G, Graves MJ, Gilbert F, Dweck M, Newby D, Fayad ZA, Reynolds G, Morgan A, Davenport AP, Jorgensen HF, Mallat Z, Bennett MR, Rudd JHF, Anury GA, Aboagye E, Barwick T, Dubash S, Jayne D, Peters J, Tarkin J Journal of the American College of Cardiology 2023, 81(4), 336-354
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
Abraham GR, Nyimanu D, Kuc RE, Maguire J, Davenport AP, Hoole SP. J Interv Cardiol. 2022:9154048.
Low-dose interleukin-2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial.
Sriranjan R, Zhao T, Kostapanos M, Tarkin J. Hoole SP, Rudd JHF, Cheriyan J, Mallat Z BMJ Open 2022;12(10):e062602
A novel approach for assessing post-infarct myocardial injury and inflammation using hybrid somatostatin receptor PET/MRI
Corovitch A, Gopalan D, Wall C, Peverelli M, Hoole SP, Calvert PA, Maughan RT, Fryer TD, Aloj L, Graves MJ, Bennett MR, Rudd JHF, Tarkin J. Circ Cardiovasc Imaging 2023 Jan;16(1):e014538.
Endothelin-1 is Increased in the Plasma of Patients Hospitalized with Covid-19.
Abraham G, Kuc R, Althage M, Greasley P, Ambery P, Maguire J, Wilkinson I, Hoole SP, Cheriyan J, Davenport A JMCC 2022; 167: 92-96
Mechanistic Study of the Effect of Endothelin SNPs in Microvascular Angina – protocol of the PRIZE Endothelin Sub-Study
Abraham GR, Morrow AJ, Dempster J, Oliveira J, Weir-McCall J, Duckworth M, Berry C, Davenport AP, Hoole SP IJC Heart & Vasculature 2022; 39: 100980
Coronary flow variations following PCI affects diastolic non-hyperemic pressure-ratios more than the whole cycle ratios.
Aetesam-ur-Rahman M, Zhao TX, Paques K, Oliveira J, Khialani B, Kyranis S, Braganza DM, Clarke SC, Bennett MR, West NEJ, Hoole SP. J Am Heart Assoc. 2022; 11 (9): e023554
Coronary imaging of cardiac allograft vasculopathy predicts current and future deterioration of left ventricular function in patients with orthotopic heart transplantation.
Reddy SA, Khialani BV, Lambert B, Floré V, Brown AJ, Pettit SV, West NEJ, Lewis C, Parameshwar J, Bhagra S, Kydd A, Hoole SP Clinical Transplantation 2022; 36 (2): e14523
Trans-myocardial blood Interleukin-6 levels relate to intracoronary imaging defined features of plaque vulnerability and predict procedure-induced myocardial infarction.
Bambrough P, Peverelli M, Brown AJ, Giblett JP, Bennett MR, West NEJ, Hoole SP CRM 2021; 39: 6-11
Coronary Flow Reserve and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Kelshiker MA*, Seligman H*, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin M, Ahmad Y, Sen S, Al-Lamee R, Petraco R, Cole G, Hoole SP, Morris PD, Rigo F, Mayet J, Francis D; Eur Heart J 2022;43(16):1582-1593.
Regulatory T cell response to low-dose interleukin-2 in patients with ischemic heart disease
Zhao TX, Sriranjan RS, Tuong ZK, Lu Y, Sage AP, Nus M, Hubsch A, Kaloyirou F, Vamvaka E, Helmy J, Kostapanos M, Klatzmann D, Tedgui A, Rudd JHF, Horton SJ, Huntly BJP, Hoole SP, Bond SP, Clatworthy MR, Cheriyan J, Mallat Z NEJM Evidence 2022; 1 (1): EVIDoa2100009
Five-year outcomes after state-of-the-art percutaneous coronary revascularization in patients with de novo three-vessel disease: final results of the SYNTAX II study
Banning AP, Serruys P, De Maria GL, Ryan N, Walsh S, Gonzalo N, van Geuns RJ, Onuma Y, Sabate M, Davies J, Lesiak M, Moreno R, Cruz-Gonzalez I, Hoole SP, Piek JJ, Appleby C, Fath-Ordoubadi F, Zaman A, Van Mieghem NM, Uren N, Zueco J, Buszman P, Iniguez A, Goicolea J, Hildick-Smith D, Ochala A, Dudek D, de Vries T, Taggart D, Farooq V, Spitzer E, Tijssen J, Escaned J EHJ 2022;43 (13): 1307-1316
Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis
Wall C, Huang Y, Le E, Ćorović A, Uy C, Gopalan D, Ma C, Manavaki R, Fryer TD, Aloj L, Graves MJ, Tombetti E, Ariff B, Bambrough P, Hoole SP, Rusk R, Jayne DR, Dweck MR, Newby D, Fayad ZA, Bennett MR, Peters JE, Slomka P, Dey D, Mason JC, Rudd JHF, Tarkin JM. European Heart J Open 2021; 1 (2): oeab019
Serial right heart catheter assessment between Balloon Pulmonary Angioplasty sessions identify procedural factors that influence response to treatment
Hug KP, Coghlan JG, Cannon J, Taboada D, Toshner M, Sheares K, Ruggiero A, Screaton N, Jenkins D, Pepke-Zaba JP, Hoole SP J Heart Lung Transplant. 2021;40(10):1223-1234.
Current Strategies for Managing CTEPH: Results of the Worldwide Prospective CTEPH Registry
Guth S, D'Armini A, Delcroix M, Nakayama K, Fadel E, Hoole SP, Jenkins D, Kiely D, Kim N, Lang I, Madani M, Matsubara H; Ogawa A, Ota-Arakaki J, Quarck R, Sadushi-Kolici R, Simonneau G, Wiedenroth C, Yildizeli B, Mayer E, Pepke-Zaba J, ERJ Open Research 2021 doi.org/10.1183/23120541.00850-2020
GLP-1 vasodilatation in humans with coronary artery disease is not adenosine mediated.
Aetesam-ur-Rahman M, Giblett JP, Khialani B, Kyranis S, Clarke SJ, Zhao TX, Braganza DM, Clarke SC, West NEJ, Bennett MR, Hoole SP. BMC Cardiovasc Disord. 2021 May 1;21(1):223. doi: 10.1186/s12872-021-02030-5.
Percutaneous Coronary Intervention in Spontaneous Coronary Artery Dissection: a balance of risk and benefit
Kotecha D, Garcia-Guimaraes M, Premawardhana D, Pellegrini D, Oliver-Williams C, Boutziouka V, Wood A, Natarajan N, Jackson R, Chan N, Rakhit R, Hoole SP, Johnson TW, Kadziela J, Ludman P, Samani NJ, Maas AHEM, Van Geuns RJ, Alfonso F and Adlam D Heart. 2021;107(17):1398-1406.
International Prospective Registry of Acute Coronary Syndromes in Patients With COVID-19
Kite TA, Ludman P, Gale CP, Wu J, Caixeta A, Mansourati J, Sabate M, Quevedo M, Candilio L, Sadeghipour P, Manjavacas A, Hoole SP, Palmer N, Arize-Sole A, Namitokov A, Escutia-Cuevas H, Vincent F, Cristea O, Ngunga M, Meray I, Morrow AJ, Arefin M, Lindsay S, Kazamel G, Sharma V, Saad A, Sinagra G, Eriksson A, Sanchez FA, Roik M, Savonitto S, Vavlukis M, Sangaraju S, Jabbour R, Kean S, Curzen N, Berry C, Stone GW, Gersh BJ, Gershlick AH On behalf of the COVID-ACS Global Registry Investigators J Am Coll Cardiol. 2021 May 25;77(20):2466-2476
Outcomes following PCI in CABG candidates during the COVID-19 Pandemic: The Prospective Multi-Centre UK-ReVasc Registry
Kite TA, Ladwiniec A, Owens CG, Chase A, Shaukat A, Mozid AM, O’Kane P, Routledge H, Perera D, Jain AK, Palmer N, Hoole SP, Egred M, Sinha MK, Cahill TJ, Candilio L, Anantharam B, Byrne J, Walsh SJ, McEntegart M, Kean S, Siddique L, Curzen N, Budgeon C, Berry C, Ludman P, Gershlick AH Catheter Cardiovasc Interv. 2022; 99 (2): 305-313.
Rituximab in Patients with Acute ST-elevation Myocardial Infarction (RITA-MI): an Experimental Medicine Safety Study
Zhao T, Hoole SP, Mallat Z Cardiovasc Res. 2022; 118 (3): 872-882
Adenosine induced Coronary Steal is observed in patients presenting with ST-elevation myocardial infarction.
Aetesam-ur-Rahman M, Brown AJ, Jaworski C, Giblett JP, Zhao T, Braganza DM, Clarke SC, Agrawal SK, Bennett MR, West NEJ, Hoole SP J Am Heart Assoc. 2021;10(13):e019899. doi: 10.1161/JAHA.120.019899.
Rationale and design of the Medical Research Council's Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) trial
Morrow AJ, Ford, TJ, Mangion K, Kotecha T, Rakhit, R, Galasko G, Hoole SP, Davenport A, Kharbanda K, Ferreira VM, Shanmuganathan M, Chiribiri, A, Perera D, Rahman H, Arnold JR, Greenwood JP, Fisher IM, Husmeier D, Hill NA, Luo X, Williams N, Miller L, Dempster J, Macfarlane PW, Welsh P, Sattar P, Whittaker A, McConnachie A, Padmanabhan S, Berry C Am Heart J 2020 229:70-80.
Balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension in the UK
Hoole SP, Coghlan JG, Cannon J, Taboada D, Toshner M, Sheares K, Fletcher A, Martinez G, Ruggiero A, Screaton N, Jenkins D and Pepke-Zaba J. Open Heart 2020 27;7(1):e001144
Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management
Al-Hussaini A, Abdelaty AMSEK, Gulsin SK, Arnold J, Garcia-Guimaraes M, Premawardhana D, Budgeon C, Wood A, Natarajan N, Mangion K, Rakhit R, Hoole SP, Johnson TW, Berry C, Hudson I, Gershlick AH, Ladwiniec A, Kovac J, Squire I, Samani NJ, Plein S, McCann GP, Adlam D European Heart Journal 2020 41(23):2197-2205
