Stephen Pettit graduated from the University of Newcastle upon Tyne, having completed a PhD in immunology during his medical training. He undertook general medical training in the West of Scotland and higher specialist training in the Mersey Deanery, including sub-specialty training at the Golden Jubilee National Hospital, Glasgow and Royal Papworth Hospital. His areas of sub-specialist interest are advanced heart failure, mechanical circulatory support and heart transplantation.
He was appointed a Consultant Cardiologist at Royal Papworth Hospital in 2014. As part of a large multi-disciplinary team, he looks after patients with advanced heart failure, patients that have undergone heart transplantation and those that are being bridged to transplantation with ventricular assist devices. He was involved in the implantation and follow-up of patients with complex pacemakers and ICDs until 2020, when he took over as Clinical Lead of the Cardiothoracic Transplant unit.
He is deputy chairperson of NHS Blood and Transplant Cardiothoracic Advisory Group, a member of the Editorial Advisory Board of the Journal of Heart and Lung Transplantation and a member of the Steering committee of the International Registry for Mechanically Assisted Circulatory Support (iMACS).
- Advanced heart failure
- Mechanical circulatory support
- Heart transplantation
- Prognostication in advanced heart failure
- Donor-recipient matching in heart transplantation
- Early allograft function after heart transplantation
- Bachelor of Medicine, Bachelor of Surgery (Honours), University of Newcastle upon Tyne, July 2002
- Doctor of Philosophy, University of Newcastle upon Tyne, July 2002
- Membership of the Royal College of Physicians (United Kingdom), June 2005
- Diploma in Mountain Medicine, UIAA/IKAR/ISMM, September 2007
- Certified Cardiac Device Specialist, International Board of Heart Rhythm Examiners, October 2011
- Certified Cardiac Device Specialist, European Heart Rhythm Association, November 2013
- Fellow of the Royal College of Physicians of London, July 2018
- Associate Fellow, Faculty of Intensive Care Medicine, July 2022
Lim HS, Bhagra S, Berman M, Kwok CS, Chue C, Ranasinghe A, Pettit S. Severe early graft dysfunction post-heart transplantation: two clinical trajectories and diastolic perfusion pressure as a predictor of mechanical circulatory support. J Heart Lung Transplant 2024; doi:10.1016/jhealun.2024.09.002 (online ahead of print). PMID 39260754
Curtain JP, Talebi A, McIntosh A, McConnachie A, O’Donnell J, Welsh P, Osmanska J, Lee M, Sonecki P, Akl T, Gopinathan V, Hurwitz J, Thiagarajan S, Pettit S, Kalra P, Patel R, Mark P, Lang N, McMurray JJV, Petrie MC, Gardner RS, Jhund PS, Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. Eur J Heart Failure 2024; 26:1383-92. PMID 38741283
Akhtar W, Baston VR, Berman M, Bhagra S, Chue C, Deakin CD, Dalzell JR, Dunning J, Dunning J, Gardner RS, Kiff K, Kore S, Lim S, MacGowan G, Naldrett I, Ostermann M, Pinto S, Pettit S, Riesgo Gil F, Rosenberg A, Rubino A, Sayeed R, Sequeira J, Swanson N, Tsui S, Walker C, Webb S, Woods A, Ventkateswaran R, Bowles CT. Joint British societies guideline on the management of emergencies in implantable left ventricular assist device recipients in transplant centres. Intensive Care Medicine 2024; 50:493-501. PMID 38526578
Watson WD, Burrage MK, Ong LP, Bhagra S, Garbi M, Pettit SJ. Right ventricular-pulmonary arterial uncoupling and ventricular-secondary mitral regurgitation: relationship with outcomes in advanced heart failure. J Heart Lung Transplant Open 2024; 4:100080.
Yim IHW, Pettit SJ, Bhagra S, Berman M, Drury NE, Lim HS. Pulmonary artery pulsatility index predicts mechanical circulatory support following heart transplantation. J Heart Lung Transplant Open 2024; 3:100030
Topriceanu CC, Alfarih M, Hughes AD, Shiwani H, Chan F, Mohiddin SA, Moody W, Steeds RP, O’Brien B, Vowinckel J, Syrris P, Coats C, Pettit S, Arbustini E, Moon JC, Captur G. The atrial and ventricular myocardial proteome of end-stage lamin heart disease. Acta Myologica 2023; 42:43-52. PMID 38090549
Papadopoulou C, Reinhold J, Grüner-Hegge N, Kydd A, Bhagra S, Parameshwar KJ, Lewis C, Martinez L, Pettit SJ. Prognostic value of three iron deficiency definitions in patients with advanced heart failure. Eur J Heart Failure 2023; 25:2067-74. PMID 37635412
Cheshire C, Messer S, Martinez L, Vokshi I, Ali J, Cernic S, Page A, Andal R, Berman M, Kaul P, Osman M, Rafiq M, Goddard M, Tweed K, Jenkins D, Tsui S, Large S, Kydd A, Lewis C, Parameshwar J, Pettit S, Bhagra S. Graft function and incidence of cardiac allograft vasculopathy in donation after circulatory determined death (DCD) heart transplant recipients. Am J Transplant 2023; 23:1570-9. PMID 37442277
Burrage MK, Cheshire C, Hey CY, Azam S, Watson WD,Bhagra S, Berman M, D’Errico L, Jenkins DP, Kaul P, Large S, Lewis C, Martinez L, Messer S, Page A, Parameshwar J, Pettit S, Rafiq M, Tsui S, Tweed K, Weir-McCall JR, Kydd A. Comparing cardiac mechanics and myocardial fibrosis in DBD and DCD heart transplant recipients. J Cardiac Failure 2023; 29:834-40. PMID 36521726
Cheshire C, Quigley R, Claydon S, Von Joel S, Osman M, Kaul P, Rafiq M, Tsui S, Jenkins DP, Berman M, Pettit S. Validation of predicted heart mass equations by measurement of donor heart mass at time of heart transplantation. Clin Transplant 2022; 36:e14773. PMID 35833312
Hey CY, Barra S, Duehmke R, Pettit S, Levy W, Silva-Cardoso J, Providencia R. An updated systematic review on heart failure treatments for patients with renal impairment: the tide is not turning. Heart Failure Reviews 2022; 27:1761-77. PMID 35129754
Bhagra SK, Pettit S, Parameshwar JK. Implantable Left Ventricular Assist Device: Indications, Eligibility and Current Outcomes. Heart 2022; 108:233-41. PMID 34099466
Cernic S, Page A, Messer S, Bhagra S, Pettit S, Dawson SN, McKie MA, Osman M, Nachum E, White D, Ali J, Fingelton L, Howlett T, Tsui S, Baxter J, Falter F, Jenkins D, Kaul P, Berman M, Catarino P, Large SR. Lactate during ex-situ heart perfusion does not predict the requirement for mechanical circulatory support following donation after circulatory death (DCD) heart transplant. J Heart Lung Transplant 2022; 41:1294-1302. PMID 35811221
Cowie MR, Flett A, Cowburn P, Foley P, Chandrasekaran B, Loke I, Critoph C, Gardner R, Guha K, Betts TR, Carr-White G, Zaidi A, Lim HS, Hayward C, Patwala A, Rogers D, Pettit S, Gazzola C, Henderson J, Adamson PB. Real-world evidence in a national health service: results of the UK CardioMEMS HF system post-market study. ESC Heart Failure 2022; 9:48-56. PMID 34882989
Santarsieri A, Rudge JF, Amin I, Butler A, Gelson W, Parmar J, Pettit S, Sharkey L, Uttenthal BJ, Follows GA. Incidence and outcomes of post-transplant lymphoproliferative disease after 5365 solid organ transplants over a 20 year period at 2 UK transplant centres. Brit J Haematol 2022; 197:310-9. PMID 35235680
Reddy SA, Khialani BV, Lambert B, Flore, V, Brown AJ, Pettit SJ, West NEJ, Lewis C, Parameshwar J, Bhagra S, Kydd A, Houle SP. Coronary imaging of cardiac allograft vasculopathy predicts current and future deterioration of left ventricular dysfunction in patients with orthotopic heart transplantation. Clin Transplant 2022; 36:e14523. PMID 34724254
Fitzsimons SJ, Evans JDW, Rassl DM, Lee KK, Strachan FE, Parameshwar J, Mills NL, Pettit SJ. High-sensitivity cardiac troponin is not associated with acute cellular rejection after heart transplantation. Transplantation 2022; 106:1024-30. PMID 34241986
Cheshire C, Kydd A, Nerkelar N, Catarino P, Brown A, Parameshwar J, Pettit S. Size matching in heart transplantation: is Predicted Heart Mass the optimal method in a United Kingdom cohort? Clin. Transplant 2021; 35:e14192. PMID 33336378
Shah N, Eyre TA, Tucker D, Kassam S, Parmar J, Suddle A, Featherstone C, Andrews P, Asgari E, Chaganti S, Menne TF, Fox CP, Pettit S, Sudde A, Bowles K. Frontline Management of Post-Transplantation Lymphoproliferative Disorder in Adult Solid Organ Recipient Patients. A British Society for Haematology Guideline. Brit J Haematol 2021; 193:727-40. PMID 33877688
Pettit SJ, Erhayiem B. Equity of Access to National Advanced Heart Failure Services. Circ Heart Fail 2021; 14: e008745. PMID 34465128
Messer S, Cernic S, Page A, Berman M, Kaul P, Colah S, Ali J, Pavlushkov E, Baxter J, Quigley R, Osman M, Nachum E, Parameshwar J, Abu-Omar Y, Dunning J, Goddard M, Bhagra S, Pettit S, Cheshire C, Lewis C, Kydd A, Ali A, Sudarshan C, Jenkins D, Tsui S, Hall R, Catarino P, Large SR. 5-year single centre early experience of heart transplantation from donation after circulatory determined death (DCD) donors. J Heart Lung Transplant 2020; 39:1463-75. PMID 33248525
Pettit SJ. HeartMate 3: Real World Performance Matches Pivotal Trial. Eur Heart J 2020; 41: 3810-12. PMID 32974667
Hudson S, Pettit SJ. What is ‘normal’ left ventricular ejection fraction? Heart 2020; 106: 1146. PMID 32719098
Ali JM, Patel S, Catarino P, Vuylsteke A, Pettit S, Bhagra S, Kydd A, Lewis C, Parameshwar J, Kaul P, Sudarshan C, Tsui S, Jenkins D, Abu-Omar Y, Berman M. Vasoplegia following heart transplantation and left ventricular assist device explant is not associated with inferior outcomes. J Thorac Dis 2020; 12:2426-34. PMID 32642148
Cesini S, Bhagra S, Pettit S. Low pulmonary artery pulsatility index is associated with adverse outcomes in ambulatory patients with advanced heart failure. J Cardiac Fail 2020; 26:352-359.
Ton V, Xie R, Hernandez-Montfort J, Meyns B, Nakatani T, Yanase M, Shaw S, Pettit S, Netuka I, Kirklin J, Goldstein D, Cowger J. Short and long-term adverse events in patients on temporary circulatory support before durable ventricular assist device: An iMACS registry analysis. J Heart Lung Transplant 2020; 39:342-352.
Hernandez-Montfort J, Xie R, Ton V, Meyns B, Nakatani T, Yanase M, Pettit S, Shaw S, Netuka I, Kirklin J, Goldstein D, Cowger J. Longitudinal impact of temporary mechanical circulatory support on durable ventricular assist device outcomes: An IMACS registry propensity matched analysis. J Heart Lung Transplant 2020; 39:145-156. PMID 31866174
Fung K, Cheshire C, Cooper JA, Catarino P, Bhagra S, Pettit S, Petersen SE. Validation of cardiovascular magnetic resonance-derived equations for predicted left ventricular mass using the UK biobank imaging cohort. Circulation Heart Fail 2019; 12:e006362.
Goldstein DJ, Meyns B, Xie R, Cowger J, Pettit S, Nakatani T, Netuka I, Shaw S, Yanase M, Kirklin JK. Third Annual Report From the ISHLT Mechanically Assisted Circulatory Support Registry: A comparison of centrifugal and axial continuous-flow left ventricular assist devices. J Heart Lung Transplant 2019; 38: 352-363.
Barra S, Duehmke R, Providencia R, Narayanan K, Reitan C, Roubicek T, Polasek R, Chow A, Pettit S, Defaye P, Fauchier L, Piot O, Deharo J-C, Sadoul N, Klug D, Garcia R, Virdee M, Agarwal S, Borgquist R, Marijon E, Boveda S. Very long-term survival and late sudden cardiac death in cardiac resynchronisation therapy patients. Eur Heart J 2019; 40: 2121-2127.
Bhagra S, Pettit SJ, Parameshwar JKP. Cardiac Transplantation – Indications, eligibility and current outcomes. Heart 2019; 105: 252-60. PMID 30209127
Pettit SJ, Petrie MC. DCD Heart Transplantation: A Song of Fire and Ice. Circ Heart Fail 2019; 12: e005991. PMID 30998399
Captur G, Arbustini E, Bonne G, Syrris P, Mills K, Wahbi K, Mohiddin SA, Pettit SJ, Ho CY, Antoine Muchir A, Gissen P, Elliott PM, Moon JC. Lamin and the Heart. Heart 2018; 104: 468-79. PMID: 29175975
Fitzsimons S, Evans J, Parameshwar J, Pettit SJ. Utility of Troponin assays for exclusion of acute cellular rejection after heart transplantation: A systematic review. J Heart Lung Transplant 2018; 37: 631-638.
Evans JDW, Dobbin S, Pettit SJ, Di Angelantonio E, Willeit P. High Sensitivity Cardiac Troponin and New Onset Heart Failure: A Systematic Review and Meta-Analysis of 67,063 individuals with 4,165 incident heart failure events. JACC Heart Fail 2018; 6: 187-197.
Pettit SJ, Orzalkiewicz M, Nawaz MA, Lewis C, Parameshwar JK, Tsui S. Retained pacemaker and implantable cardioverter-defibrillator components after heart transplantation are common and may lead to adverse events. Europace 2018; 20: 1312-1317.
Messer S, Page A, Axell R, Berman M, Hernández-Sánchez J, Colah S, Parizkova B, Valchanov K, Dunning J, Pavlushkov E, Balasubramanian SK, Parameshwar J, Abu Omar Y, Goddard M, Pettit S, Lewis C, Kydd A, Jenkins D, Watson CJ, Sudarshan C, Catarino P, Findlay M, Ali A, Tsui S, LargeSR. Outcome Following Heart Transplantation from Donation After Circulatory Determined Death (DCD) Donors. J Heart Lung Transplant 2017; 36: 1311-1318.
Evans JDW, Kaptoge S, Caleyachetty R, Di Angelantonio E, Lewis C, Parameshwar KJ, Pettit SJ. Socioeconomic deprivation and survival after heart transplantation in England: an analysis of the United Kingdom Transplant Registry. Circulation Cardiovasc Qual Outcomes 2016; 9:695-703.
Evans JDW, Pettit SJ, Goddard M, Lewis C, Parameshwar KJ. Alemtuzumab as a novel treatment for refractory giant cell myocarditis after heart transplantation. J Heart Lung Transplant 2016;35:256-258.
Pettit SJ, Shapiro LM, Lewis C, Parameshwar JK, Tsui SSL. Percutaneous withdrawal of HeartWare HVAD left ventricular assist device support. J Heart Lung Transplant 2015;34:990-992.
Pettit SJ, Jhund PS, Hawkins NM, Gardner RS, Haj-Yahia S, McMurray JJV, Petrie MC. How small is too small? A systematic review of centre volume and outcome after cardiac transplantation. Circulation Cardiovasc Qual Outcomes 2012;5:783-790.
