Dr Ruggiero qualified as a doctor at the University of Rome - Campus Biomedico and trained in general radiology in Rome. He undertook the two-year R25T Molecular Imaging for Oncology Fellowship at Memorial Sloan-Kettering Cancer Center (New York, USA) and then he moved to the Erasmus University Medical Center in Rotterdam (The Netherlands). He was awarded a PhD from Erasmus University in 2012.
He obtained his subspecialty training in Cambridge (UK) at Addenbrooke’s hospital (cross sectional radiology), Papworth Hospital (cardio-thoracic radiology) and Southampton University hospital (cardiac MR). He is currently working as consultant cardio-thoracic radiologist in Papworth Hospital. He covers the full range of cardio-thoracic imaging including cardiac MRI and interventional cardio-thoracic diagnostic procedures. He is a member of the pulmonary vascular disease unit at Papworth Hospital.
He trained and performed research in advanced methods of nuclear and optical imaging within the department of Radiology and Nuclear medicine at Memorial Sloan-Kettering Cancer Center in New York. His research was focused on innovative approaches of response to therapy by using 89Zr-radiololabelled anti-PSMA antibodies in prostate cancer and on novel carbon nanotubes platforms for targeted imaging. Also, here he produced some of the earliest publications on the use of Cerenkov luminescence imaging. His PhD work focused on the noninvasive imaging (bioluminescence and 7T MR imaging) of stem cells implanted in the heart.Dr Ruggiero qualified as a doctor at the University of Rome - Campus Biomedico and trained in general radiology in Rome. He undertook the two-year R25T Molecular Imaging for Oncology Fellowship at Memorial Sloan-Kettering Cancer Center (New York, USA) and then he moved to the Erasmus University Medical Center in Rotterdam (The Netherlands). He was awarded a PhD from Erasmus University in 2012.
He obtained his subspecialty training in Cambridge (UK) at Addenbrooke’s hospital (cross sectional radiology), Papworth Hospital (cardio-thoracic radiology) and Southampton University hospital (cardiac MR). He is currently working as consultant cardio-thoracic radiologist in Papworth Hospital. He covers the full range of cardio-thoracic imaging including cardiac MRI and interventional cardio-thoracic diagnostic procedures. He is a member of the pulmonary vascular disease unit at Papworth Hospital.
He trained and performed research in advanced methods of nuclear and optical imaging within the department of Radiology and Nuclear medicine at Memorial Sloan-Kettering Cancer Center in New York. His research was focused on innovative approaches of response to therapy by using 89Zr-radiololabelled anti-PSMA antibodies in prostate cancer and on novel carbon nanotubes platforms for targeted imaging. Also, here he produced some of the earliest publications on the use of Cerenkov luminescence imaging. His PhD work focused on the noninvasive imaging (bioluminescence and 7T MR imaging) of stem cells implanted in the heart.
Cardiovascular CT and MR Imaging, Thoracic Oncology, Pulmonary Hypertension
Imaging of pulmonary hypertension; Cerenkov luminescence imaging for oncology; Artificial intelligence for Imaging
MD - University of Rome
PhD - Erasmus University
Member of the General Medical Council
Member of the Royal College of Radiologists
Member of the European Association in Cardiovascular imaging
Member of the European Society of Radiology and European Society of Cardiac Imaging
Member of the Radiological Society of North America
View Dr Ruggiero's Publications on PubMed
Alidori S, Bowman RL, Yarilin D, Barlas A, Mulvey JJ, Xu Ke, Ruggiero A, Manova-Todorova K, Scheinberg DA, McDevitt MR. Deconvoluting hepatic processing of carbon nanotubes. Nat Commun. 2016 Jul 29;7:12343
Behling K, Maguire W, DiGialleonardo V, Ruggiero A, Sprinkle S, Puebla J, Sheth A, Keshari K, Gutin P, Scheinberg D, McDevitt MR. Alpha-particle therapy directed to the vascular endothelium of glioblastoma. J Nucl Med. 2016 Apr 28 [epub ahead of print]
Ruggiero A, Schiavon G, Bekers DJ, Barry PA, Sleijfer S, Kloth J Krestin GP, Schöffski P, Verweij J, Mathijssen RHJ. The Effect of Baseline Morphology and its Change during Treatment on the Accuracy of RECIST in Assessment of Liver Metastases. Eur J Cancer. 2014 Mar;50(5):972-80.
Ruggiero A, Guenoun J, Schmidt H, Doeswijk GN, Klein S, Houston GC, Krestin GP, Kotek G, Bernsen MR. In vivo MRI mapping of iron oxide labelled stem cells transplanted in the heart. Contrast Media Mol Imaging. 2013 Nov-Dec;8(6):487-94
Ruggiero A, Guenoun J, Doeswijk G, Janssens RC, Koning GA, Kotek G, Krestin GP, Bernsen MR. In vivo quantitative assessment of cell viability of gadolinium or iron-labeled cells using MRI and bioluminescence imaging. Contrast Media Mol Imaging. 2013 Mar-Apr;8(2):165-74
Bernsen MR, Ruggiero A, van Straten M, Kotek G, Haeck JC, Wielopolski PA, Krestin GP. Computed tomography and magnetic resonance imaging. Molecular Imaging in Oncology. Recent Results Cancer Res. 2013;187:3-63
Schiavon G, Ruggiero A, Schöffski P, van der Holt B, Bekers DJ, Eechoute K, Vandecaveye V, Krestin GP, Verweij J, Sleijfer S, Mathijssen RHJ. Tumor volume as an alternative response measurement for imatinib treated GIST patients. PLoS One. 2012;7(11):e48372
Ruggiero A, Thorek DL, Guenoun J, Krestin GP, Bernsen MR. Cell tracking in cardiac repair: what to image and how to image. Eur Radiol. 2012 Jan;22(1):189-204.
Santini D, Schiavon G, Vincenzi B, Gaeta L, Pantano F, Russo A, Ortega C, Porta C, Galluzzo S, Armento G, La Verde N, Caroti C, Treilleux I, Ruggiero A, Perrone G, Addeo R, Clezardin P, Muda AO, Tonini G. Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients. PLoS One. 2011 Apr 29;6(4):e19234.
Ruggiero A, Holland JP, Hudolin T, Shenker L, Kulova A, Bander NH, Lewis J, Grimm J. Monitoring response to therapy with anti-PSMA radiolabeled antibody in prostate cancer. J Nucl Med. 2011 Oct;52(10):1608-15
Holland JP, Normand G, Ruggiero A, Lewis JS, Grimm J. Intra-operative imaging of PET radiotracers using Cerenkov luminescence emissions. Mol Imaging. 2011 Jun;10(3):177-86, 1-3.
Multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia.
Mallikaratchy PR, Ruggiero A, Gardner JR, Kuryavyi V, Maguire WF, Heaney ML, McDevitt MR; Patel DJ, Scheinberg DA. Nucleic Acids Res. 2010 Oct 28.
Ruggiero A, Villa CH, Holland JP, Sprinkle SR, May C, Lewis JS, Scheinberg DA, McDevitt MR. Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes. International Journal of Nanomedicine 2010:5 783–802.
Ruggiero A, Villa C, Bander E, Rey DA, Bergkvist M, Batt CA, Manova-Todorova K, Deen WM, Scheinberg DA, McDevitt MR. Paradoxical glomerular filtration of carbon nanotubes. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12369-74.
Ruggiero A, Holland JP, Lewis JS, Grimm J. Cerenkov luminescence imaging of medical isotopes. J Nucl Med. 2010 Jul;51(7):1123-30
Ruggiero A, Brader P, Serganova I, Zanzonico P, Hricak H, Lipman N, Blasberg RG. Different strategies for reducing Intestinal background radioactivity associated with imaging HSV1- tk expression using established radionucleoside probes. Mol Imaging 2010 Feb;9(1):47-58
Afeltra A, Zennaro D, Garzia P, Ruggiero A, Dardes N, Navajas MF, Zobel BB, Amoroso A. Prevalence of interstitial lung involvement in patients with connective tissue diseases assessed with high-resolution computed tomography. Scand J Rheumatol 2006 Sep-Oct;35(5):388-94
